Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/5147 |
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| author | Wanting Hou Ruiqi Liu Siwei Bi Qian He Haibo Wang Jun Gu |
| author_facet | Wanting Hou Ruiqi Liu Siwei Bi Qian He Haibo Wang Jun Gu |
| author_sort | Wanting Hou |
| collection | DOAJ |
| description | Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (<i>N,N’</i>-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy. |
| first_indexed | 2024-03-10T15:03:51Z |
| format | Article |
| id | doaj.art-3abf1081feb24dd0939a2ecaeb412e16 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:03:51Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3abf1081feb24dd0939a2ecaeb412e162023-11-20T19:53:36ZengMDPI AGMolecules1420-30492020-11-012521514710.3390/molecules25215147Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical ApplicationsWanting Hou0Ruiqi Liu1Siwei Bi2Qian He3Haibo Wang4Jun Gu5Department of Medical Oncology Cancer Center, West China Hospital, Sichuan University, Chengdu 610000, Sichuan, ChinaDepartment of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610000, Sichuan, ChinaDepartment of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610000, Sichuan, ChinaDepartment of Emergency, West China Hospital, Sichuan University, Chengdu 610000, Sichuan, ChinaCollege of Biomass Science and Engineering, Sichuan University, Chengdu 610000, Sichuan, ChinaDepartment of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610000, Sichuan, ChinaDue to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (<i>N,N’</i>-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.https://www.mdpi.com/1420-3049/25/21/5147photo-responsive polymersomeshydrophilic drugshydrophobic drugs |
| spellingShingle | Wanting Hou Ruiqi Liu Siwei Bi Qian He Haibo Wang Jun Gu Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications Molecules photo-responsive polymersomes hydrophilic drugs hydrophobic drugs |
| title | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
| title_full | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
| title_fullStr | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
| title_full_unstemmed | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
| title_short | Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications |
| title_sort | photo responsive polymersomes as drug delivery system for potential medical applications |
| topic | photo-responsive polymersomes hydrophilic drugs hydrophobic drugs |
| url | https://www.mdpi.com/1420-3049/25/21/5147 |
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