Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia
Hypertensive disorders during pregnancy constitute one of the main causes of maternal and perinatal morbidity and mortality across the world and particularly in developing countries such as Ecuador. However, despite its impact on public health, the primary pathophysiological processes involved are y...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01561/full |
| _version_ | 1818847577916833792 |
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| author | Enrique Teran Isabel Hernández Isabel Hernández Leandro Tana Santiago Teran Carlos Galaviz-Hernandez Martha Sosa-Macías Gustavo Molina Andrés Calle |
| author_facet | Enrique Teran Isabel Hernández Isabel Hernández Leandro Tana Santiago Teran Carlos Galaviz-Hernandez Martha Sosa-Macías Gustavo Molina Andrés Calle |
| author_sort | Enrique Teran |
| collection | DOAJ |
| description | Hypertensive disorders during pregnancy constitute one of the main causes of maternal and perinatal morbidity and mortality across the world and particularly in developing countries such as Ecuador. However, despite its impact on public health, the primary pathophysiological processes involved are yet to be elucidated. It has been proposed, among other theories, that an abnormal placentation may induce an endothelial dysfunction, which is ultimately responsible for the final clinical manifestations. Mitochondria, particularly from trophoblastic cells, are responsible for the production of energy, which is extremely important for normal placentation. The malfunction in this supply of energy may produce higher levels of free radicals. In both production of energy and free radicals, coenzyme Q10 (CoQ10) plays a crucial role in electron transport. As such, the role of CoQ10 in the genesis and prevention of preeclampsia has become the focus of a number of research groups, including that of the authors. Developing an in-depth understanding of these mechanisms might allow us to design new and feasible strategies with which we can reduce preeclampsia, particularly in the Latin-American countries. |
| first_indexed | 2024-12-19T06:03:40Z |
| format | Article |
| id | doaj.art-3ac173be5daf4c39a05a28fce57ea8a2 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-19T06:03:40Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-3ac173be5daf4c39a05a28fce57ea8a22022-12-21T20:33:12ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-11-01910.3389/fphys.2018.01561418672Mitochondria and Coenzyme Q10 in the Pathogenesis of PreeclampsiaEnrique Teran0Isabel Hernández1Isabel Hernández2Leandro Tana3Santiago Teran4Carlos Galaviz-Hernandez5Martha Sosa-Macías6Gustavo Molina7Andrés Calle8Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, EcuadorColegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, EcuadorFacultad de Enfermería, Pontificia Universidad Católica del Ecuador, Quito, EcuadorColegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, EcuadorColegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, EcuadorInstituto Politécnico Nacional, Durango, MexicoInstituto Politécnico Nacional, Durango, MexicoColegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, EcuadorFacultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, EcuadorHypertensive disorders during pregnancy constitute one of the main causes of maternal and perinatal morbidity and mortality across the world and particularly in developing countries such as Ecuador. However, despite its impact on public health, the primary pathophysiological processes involved are yet to be elucidated. It has been proposed, among other theories, that an abnormal placentation may induce an endothelial dysfunction, which is ultimately responsible for the final clinical manifestations. Mitochondria, particularly from trophoblastic cells, are responsible for the production of energy, which is extremely important for normal placentation. The malfunction in this supply of energy may produce higher levels of free radicals. In both production of energy and free radicals, coenzyme Q10 (CoQ10) plays a crucial role in electron transport. As such, the role of CoQ10 in the genesis and prevention of preeclampsia has become the focus of a number of research groups, including that of the authors. Developing an in-depth understanding of these mechanisms might allow us to design new and feasible strategies with which we can reduce preeclampsia, particularly in the Latin-American countries.https://www.frontiersin.org/article/10.3389/fphys.2018.01561/fullpreeclampsiaplacentamitochondriacoenzyme Q10pregnancy |
| spellingShingle | Enrique Teran Isabel Hernández Isabel Hernández Leandro Tana Santiago Teran Carlos Galaviz-Hernandez Martha Sosa-Macías Gustavo Molina Andrés Calle Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia Frontiers in Physiology preeclampsia placenta mitochondria coenzyme Q10 pregnancy |
| title | Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia |
| title_full | Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia |
| title_fullStr | Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia |
| title_full_unstemmed | Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia |
| title_short | Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia |
| title_sort | mitochondria and coenzyme q10 in the pathogenesis of preeclampsia |
| topic | preeclampsia placenta mitochondria coenzyme Q10 pregnancy |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01561/full |
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