On the epigenetics of vascular regulation and disease
<p>Abstract</p> <p>Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. The modulation of gene expression through modification...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-05-01
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| Series: | Clinical Epigenetics |
| Subjects: | |
| Online Access: | http://www.clinicalepigeneticsjournal.com/content/4/1/7 |
| _version_ | 1811297422379319296 |
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| author | Schleithoff Christina Voelter-Mahlknecht Susanne Dahmke Indra Mahlknecht Ulrich |
| author_facet | Schleithoff Christina Voelter-Mahlknecht Susanne Dahmke Indra Mahlknecht Ulrich |
| author_sort | Schleithoff Christina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. The modulation of gene expression through modification of the epigenome by structural changes of the chromatin architecture without alterations of the associated genomic DNA sequence is part of the cellular response to environmental changes. Such environmental conditions, which are finally being translated into adaptations of the cardiovascular system, also comprise pathological conditions such as atherosclerosis or myocardial infarction. This review summarizes recent findings on the epigenetics of vascular regulation and disease and presents nutritional and pharmacological approaches as novel epigenetic strategies in the prevention and treatment of cardiovascular disease.</p> |
| first_indexed | 2024-04-13T06:04:04Z |
| format | Article |
| id | doaj.art-3ac3784b7fad4163a9c69cc13cc08d52 |
| institution | Directory Open Access Journal |
| issn | 1868-7083 |
| language | English |
| last_indexed | 2024-04-13T06:04:04Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj.art-3ac3784b7fad4163a9c69cc13cc08d522022-12-22T02:59:20ZengBMCClinical Epigenetics1868-70832012-05-0141710.1186/1868-7083-4-7On the epigenetics of vascular regulation and diseaseSchleithoff ChristinaVoelter-Mahlknecht SusanneDahmke IndraMahlknecht Ulrich<p>Abstract</p> <p>Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. The modulation of gene expression through modification of the epigenome by structural changes of the chromatin architecture without alterations of the associated genomic DNA sequence is part of the cellular response to environmental changes. Such environmental conditions, which are finally being translated into adaptations of the cardiovascular system, also comprise pathological conditions such as atherosclerosis or myocardial infarction. This review summarizes recent findings on the epigenetics of vascular regulation and disease and presents nutritional and pharmacological approaches as novel epigenetic strategies in the prevention and treatment of cardiovascular disease.</p>http://www.clinicalepigeneticsjournal.com/content/4/1/7EpigeneticsCardiovascular diseaseVascular regulationSirtuinsHistone deacetylaseHDAC |
| spellingShingle | Schleithoff Christina Voelter-Mahlknecht Susanne Dahmke Indra Mahlknecht Ulrich On the epigenetics of vascular regulation and disease Clinical Epigenetics Epigenetics Cardiovascular disease Vascular regulation Sirtuins Histone deacetylase HDAC |
| title | On the epigenetics of vascular regulation and disease |
| title_full | On the epigenetics of vascular regulation and disease |
| title_fullStr | On the epigenetics of vascular regulation and disease |
| title_full_unstemmed | On the epigenetics of vascular regulation and disease |
| title_short | On the epigenetics of vascular regulation and disease |
| title_sort | on the epigenetics of vascular regulation and disease |
| topic | Epigenetics Cardiovascular disease Vascular regulation Sirtuins Histone deacetylase HDAC |
| url | http://www.clinicalepigeneticsjournal.com/content/4/1/7 |
| work_keys_str_mv | AT schleithoffchristina ontheepigeneticsofvascularregulationanddisease AT voeltermahlknechtsusanne ontheepigeneticsofvascularregulationanddisease AT dahmkeindra ontheepigeneticsofvascularregulationanddisease AT mahlknechtulrich ontheepigeneticsofvascularregulationanddisease |