Perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high-resolution computed tomography
The term amyloidosis describes a group of diseases caused by the fibrillar deposit of poorly folded proteins in tissues with a secondary alteration of their function. Diffuse parenchymal lung disease associated with amyloidosis is rare and is most often diagnosed in autopsy. A 45-year-old male patie...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043321000273 |
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| author | José Fernando Polo-Nieto, MD Maria Del Pilar Quiroga-Dussan, MD Juan Pablo Castañeda-González Diana Marcela Fierro-Rodríguez, MD Ricardo Durán-Acuña, MD Jorge Alberto Carrillo-Bayona, MD |
| author_facet | José Fernando Polo-Nieto, MD Maria Del Pilar Quiroga-Dussan, MD Juan Pablo Castañeda-González Diana Marcela Fierro-Rodríguez, MD Ricardo Durán-Acuña, MD Jorge Alberto Carrillo-Bayona, MD |
| author_sort | José Fernando Polo-Nieto, MD |
| collection | DOAJ |
| description | The term amyloidosis describes a group of diseases caused by the fibrillar deposit of poorly folded proteins in tissues with a secondary alteration of their function. Diffuse parenchymal lung disease associated with amyloidosis is rare and is most often diagnosed in autopsy. A 45-year-old male patient presented an acute episode of cough with mucoid expectoration. He had also dyspnea, dry cough, chest pain, and constitutional symptoms of 6 months of evolution. Initially the case was treated as acute pneumonia. After taking radiological images of the thorax, a diagnostic suspicion of lymphangitic spread of neoplasia was assumed. Histopathological findings of an open pulmonary biopsy demonstrated interstitial thickening with perivascular eosinophilic invasion. Congo Red staining and immunohistochemistry studies were done and turned out to be positive for amyloid. The perilymphatic micronodular pattern as a radiological manifestation of parenchymal pulmonary amyloidosis has been very rarely described in the literature, therefore it must be considered as a differential diagnosis in patients with this pattern in CT scan and should be an incentive for its histopathological study once a neoplasm is ruled out. |
| first_indexed | 2024-12-13T12:21:42Z |
| format | Article |
| id | doaj.art-3ac4551b7816494c8e86d3a178299521 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-12-13T12:21:42Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-3ac4551b7816494c8e86d3a1782995212022-12-21T23:46:33ZengElsevierRadiology Case Reports1930-04332021-04-01164850854Perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high-resolution computed tomographyJosé Fernando Polo-Nieto, MD0Maria Del Pilar Quiroga-Dussan, MD1Juan Pablo Castañeda-González2Diana Marcela Fierro-Rodríguez, MD3Ricardo Durán-Acuña, MD4Jorge Alberto Carrillo-Bayona, MD5Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; Department of Pathology. Hospital de San José, Bogotá, ColombiaFundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; Department of Pathology. Hospital de San José, Bogotá, ColombiaFundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; Department of Pathology. Hospital de San José, Bogotá, Colombia; Corresponding author.Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; Department of Radiology. Hospital de San José, Bogotá, ColombiaFundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; Department of Pulmonology. Hospital de San José, Bogotá, ColombiaFundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; Department of Radiology. Hospital de San José, Bogotá, ColombiaThe term amyloidosis describes a group of diseases caused by the fibrillar deposit of poorly folded proteins in tissues with a secondary alteration of their function. Diffuse parenchymal lung disease associated with amyloidosis is rare and is most often diagnosed in autopsy. A 45-year-old male patient presented an acute episode of cough with mucoid expectoration. He had also dyspnea, dry cough, chest pain, and constitutional symptoms of 6 months of evolution. Initially the case was treated as acute pneumonia. After taking radiological images of the thorax, a diagnostic suspicion of lymphangitic spread of neoplasia was assumed. Histopathological findings of an open pulmonary biopsy demonstrated interstitial thickening with perivascular eosinophilic invasion. Congo Red staining and immunohistochemistry studies were done and turned out to be positive for amyloid. The perilymphatic micronodular pattern as a radiological manifestation of parenchymal pulmonary amyloidosis has been very rarely described in the literature, therefore it must be considered as a differential diagnosis in patients with this pattern in CT scan and should be an incentive for its histopathological study once a neoplasm is ruled out.http://www.sciencedirect.com/science/article/pii/S1930043321000273AmyloidosisLung diseaseHematological diseaseX-ray computed tomography |
| spellingShingle | José Fernando Polo-Nieto, MD Maria Del Pilar Quiroga-Dussan, MD Juan Pablo Castañeda-González Diana Marcela Fierro-Rodríguez, MD Ricardo Durán-Acuña, MD Jorge Alberto Carrillo-Bayona, MD Perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high-resolution computed tomography Radiology Case Reports Amyloidosis Lung disease Hematological disease X-ray computed tomography |
| title | Perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high-resolution computed tomography |
| title_full | Perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high-resolution computed tomography |
| title_fullStr | Perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high-resolution computed tomography |
| title_full_unstemmed | Perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high-resolution computed tomography |
| title_short | Perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high-resolution computed tomography |
| title_sort | perilymphatic micronodular pattern as a manifestation of pulmonary amyloidosis on high resolution computed tomography |
| topic | Amyloidosis Lung disease Hematological disease X-ray computed tomography |
| url | http://www.sciencedirect.com/science/article/pii/S1930043321000273 |
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