ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors
Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology. A potent P2Y1R agonist, adenosine 5′-O-(2-thiotriphosphate), binds the A1R binding pocket of the A1R/P2Y1R complex and inhibits adenylyl cyclase...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2004-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319325095 |
| _version_ | 1811328317668720640 |
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| author | Kazuaki Yoshioka Hiroyasu Nakata |
| author_facet | Kazuaki Yoshioka Hiroyasu Nakata |
| author_sort | Kazuaki Yoshioka |
| collection | DOAJ |
| description | Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology. A potent P2Y1R agonist, adenosine 5′-O-(2-thiotriphosphate), binds the A1R binding pocket of the A1R/P2Y1R complex and inhibits adenylyl cyclase activity via Gi/o protein. These mechanisms might be used to fine-tune purinergic inhibition locally at sites where there is a particular oligomerization structure between purinergic receptors and explain the undefined purinergic functions by adenosine and adenine nucleotides. Keywords:: oligomerization, purinergic receptor, bioluminescence resonance energy transfer system (BRET), immunoprecipitation, G protein-coupled receptor |
| first_indexed | 2024-04-13T15:23:03Z |
| format | Article |
| id | doaj.art-3ac99a7413fe4b75a9aa221469581915 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-13T15:23:03Z |
| publishDate | 2004-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-3ac99a7413fe4b75a9aa2214695819152022-12-22T02:41:35ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-019428894ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine ReceptorsKazuaki Yoshioka0Hiroyasu Nakata1Department of Molecular Cell Signaling, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526, JapanDepartment of Molecular Cell Signaling, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526, Japan; Corresponding author. FAX: +81-42-321-8678 E-mail: nakata@tmin.ac.jpAdenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology. A potent P2Y1R agonist, adenosine 5′-O-(2-thiotriphosphate), binds the A1R binding pocket of the A1R/P2Y1R complex and inhibits adenylyl cyclase activity via Gi/o protein. These mechanisms might be used to fine-tune purinergic inhibition locally at sites where there is a particular oligomerization structure between purinergic receptors and explain the undefined purinergic functions by adenosine and adenine nucleotides. Keywords:: oligomerization, purinergic receptor, bioluminescence resonance energy transfer system (BRET), immunoprecipitation, G protein-coupled receptorhttp://www.sciencedirect.com/science/article/pii/S1347861319325095 |
| spellingShingle | Kazuaki Yoshioka Hiroyasu Nakata ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors Journal of Pharmacological Sciences |
| title | ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors |
| title_full | ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors |
| title_fullStr | ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors |
| title_full_unstemmed | ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors |
| title_short | ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors |
| title_sort | atp and adenosine mediated signaling in the central nervous system purinergic receptor complex generating adenine nucleotide sensitive adenosine receptors |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319325095 |
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