Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision decline
Alcohol addiction often compromises vision by impairing the visual pathway, particularly the retina and optic nerve. Vision decline in alcoholics consists of a sequential transition from reversible functional deterioration of the visual pathway to irreversible clinical vision degeneration or vision...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2022.912883/full |
| _version_ | 1818484222746165248 |
|---|---|
| author | Xin Xie Kang Feng Juan Wang Min Zhang Jing Hong Haolin Zhang |
| author_facet | Xin Xie Kang Feng Juan Wang Min Zhang Jing Hong Haolin Zhang |
| author_sort | Xin Xie |
| collection | DOAJ |
| description | Alcohol addiction often compromises vision by impairing the visual pathway, particularly the retina and optic nerve. Vision decline in alcoholics consists of a sequential transition from reversible functional deterioration of the visual pathway to irreversible clinical vision degeneration or vision loss. Thus, the control of alcoholic vision decline should focus on prevention before permanent damage occurs. Visual electrophysiology is a promising method for early detection of retinal dysfunction and optic neuropathy, including full-field electroretinography (ffERG) and pattern-reversal visual evoked potential (PR-VEP). So far, however, research studying the electrophysiological characteristics in the preclinical stage of vision decline caused by alcohol addiction is still lacking. Here we conducted a retrospective study with 11 alcoholics and 14 matched control individuals to address this need. We had performed comprehensive visual electrophysiological tests, including ffERG and PR-VEP. We next analyzed all electrophysiological parameters using multivariate statistical analyses and discovered some highly sensitive alterations to alcohol addiction. We found severely reduced amplitudes in scotopic ffERG oscillatory potentials (OPs) in alcohol addicts. These changes indicate the alcohol-induced disturbances of amacrine cells and retinal circulation. In subjects with alcohol addiction, the amplitudes of b-waves diminish significantly in scotopic but not photopic ffERG, implying the impaired function of the retinal rod system and the dysfunction of the inner retina. PR-VEPs elicited by checkerboard stimuli with large 1 degree (°) checks mainly reflect the state of the optic nerve and ganglion cells, and PR-VEPs provoked by small 0.25° checks mainly reflect the function of the macular. We performed both measurements and observed a robust amplitude reduction in all three peaks (N75–P100, P100–N135) and a significant peak time extension in P100. Our research provides an affordable and non-invasive tool to accurately evaluate visual pathway conditions in alcohol addicts and help clinicians take targeted treatment. |
| first_indexed | 2024-12-10T15:52:16Z |
| format | Article |
| id | doaj.art-3ac99b5c242f4d41984840c6adce5b2d |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-10T15:52:16Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-3ac99b5c242f4d41984840c6adce5b2d2022-12-22T01:42:45ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102022-08-011610.3389/fncir.2022.912883912883Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision declineXin Xie0Kang Feng1Juan Wang2Min Zhang3Jing Hong4Haolin Zhang5Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Eye Center, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Eye Center, Peking University Third Hospital, Beijing, ChinaFaculty of Environment and Life, Beijing University of Technology, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Eye Center, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Eye Center, Peking University Third Hospital, Beijing, ChinaFaculty of Environment and Life, Beijing University of Technology, Beijing, ChinaAlcohol addiction often compromises vision by impairing the visual pathway, particularly the retina and optic nerve. Vision decline in alcoholics consists of a sequential transition from reversible functional deterioration of the visual pathway to irreversible clinical vision degeneration or vision loss. Thus, the control of alcoholic vision decline should focus on prevention before permanent damage occurs. Visual electrophysiology is a promising method for early detection of retinal dysfunction and optic neuropathy, including full-field electroretinography (ffERG) and pattern-reversal visual evoked potential (PR-VEP). So far, however, research studying the electrophysiological characteristics in the preclinical stage of vision decline caused by alcohol addiction is still lacking. Here we conducted a retrospective study with 11 alcoholics and 14 matched control individuals to address this need. We had performed comprehensive visual electrophysiological tests, including ffERG and PR-VEP. We next analyzed all electrophysiological parameters using multivariate statistical analyses and discovered some highly sensitive alterations to alcohol addiction. We found severely reduced amplitudes in scotopic ffERG oscillatory potentials (OPs) in alcohol addicts. These changes indicate the alcohol-induced disturbances of amacrine cells and retinal circulation. In subjects with alcohol addiction, the amplitudes of b-waves diminish significantly in scotopic but not photopic ffERG, implying the impaired function of the retinal rod system and the dysfunction of the inner retina. PR-VEPs elicited by checkerboard stimuli with large 1 degree (°) checks mainly reflect the state of the optic nerve and ganglion cells, and PR-VEPs provoked by small 0.25° checks mainly reflect the function of the macular. We performed both measurements and observed a robust amplitude reduction in all three peaks (N75–P100, P100–N135) and a significant peak time extension in P100. Our research provides an affordable and non-invasive tool to accurately evaluate visual pathway conditions in alcohol addicts and help clinicians take targeted treatment.https://www.frontiersin.org/articles/10.3389/fncir.2022.912883/fullalcohol addictionelectrophysiology of visionelectroretinogram (ERG)visual evoked potential (VEP)multivariate statistical analyses (MVA) |
| spellingShingle | Xin Xie Kang Feng Juan Wang Min Zhang Jing Hong Haolin Zhang Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision decline Frontiers in Neural Circuits alcohol addiction electrophysiology of vision electroretinogram (ERG) visual evoked potential (VEP) multivariate statistical analyses (MVA) |
| title | Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision decline |
| title_full | Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision decline |
| title_fullStr | Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision decline |
| title_full_unstemmed | Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision decline |
| title_short | Comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans: Clinical values in early prevention of alcoholic vision decline |
| title_sort | comprehensive visual electrophysiological measurements discover crucial changes caused by alcohol addiction in humans clinical values in early prevention of alcoholic vision decline |
| topic | alcohol addiction electrophysiology of vision electroretinogram (ERG) visual evoked potential (VEP) multivariate statistical analyses (MVA) |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2022.912883/full |
| work_keys_str_mv | AT xinxie comprehensivevisualelectrophysiologicalmeasurementsdiscovercrucialchangescausedbyalcoholaddictioninhumansclinicalvaluesinearlypreventionofalcoholicvisiondecline AT kangfeng comprehensivevisualelectrophysiologicalmeasurementsdiscovercrucialchangescausedbyalcoholaddictioninhumansclinicalvaluesinearlypreventionofalcoholicvisiondecline AT juanwang comprehensivevisualelectrophysiologicalmeasurementsdiscovercrucialchangescausedbyalcoholaddictioninhumansclinicalvaluesinearlypreventionofalcoholicvisiondecline AT minzhang comprehensivevisualelectrophysiologicalmeasurementsdiscovercrucialchangescausedbyalcoholaddictioninhumansclinicalvaluesinearlypreventionofalcoholicvisiondecline AT jinghong comprehensivevisualelectrophysiologicalmeasurementsdiscovercrucialchangescausedbyalcoholaddictioninhumansclinicalvaluesinearlypreventionofalcoholicvisiondecline AT haolinzhang comprehensivevisualelectrophysiologicalmeasurementsdiscovercrucialchangescausedbyalcoholaddictioninhumansclinicalvaluesinearlypreventionofalcoholicvisiondecline |