Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study
<p>Abstract</p> <p>Background</p> <p>Genes involved in dopaminergic neurotransmission have been suggested as candidates for involvement in smoking behavior. We hypothesized that alleles associated with reduced dopaminergic neurotransmission would be more common in conti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2007-04-01
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| Series: | Behavioral and Brain Functions |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/3/1/22 |
| _version_ | 1811266819925737472 |
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| author | Srinouanprachan Sengkeo Bowen Deborah J Rossing Mary Ton Thanh GN Wicklund Kristine Farin Federico M |
| author_facet | Srinouanprachan Sengkeo Bowen Deborah J Rossing Mary Ton Thanh GN Wicklund Kristine Farin Federico M |
| author_sort | Srinouanprachan Sengkeo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Genes involved in dopaminergic neurotransmission have been suggested as candidates for involvement in smoking behavior. We hypothesized that alleles associated with reduced dopaminergic neurotransmission would be more common in continuing smokers than among women who quit smoking.</p> <p>Methods</p> <p>The study included 593 women aged 26–65 years who participated in a twelve month smoking cessation trial conducted in 1993–1994. Participants were contacted three years after the trial to obtain updated smoking history and biological specimens. Seven polymorphisms were assessed in genes involved in dopamine synthesis (tyrosine hydoxylase [<it>TH</it>]), receptor activation (dopamine receptors [<it>DRD2</it>, <it>DRD3</it>, <it>DRD4</it>]), reuptake (dopamine transporter [<it>SLC6A3</it>]), and metabolism (catechol-o-methyltransferase [<it>COMT</it>]). Smoking cessation was assessed as "short-term" quitting (abstinence for the seven days before the conclusion of the trial) and "long-term" quitting (abstinence for the six months before a subsequent interview conducted several years later).</p> <p>Results</p> <p>We observed no association of any polymorphism with either short- or long-term quitting. Although some relative risk estimates were consistent with weak associations, either the direction of effect was opposite of that hypothesized, or results of the short- and long-term cessation endpoints differed. However, effect modification on smoking cessation was observed between DRD2 Taq1A and SLC6A3 VNTR polymorphisms, DRD3 Ser/Gly and d,1-fenfluramine, and DRD4 VNTR and d,1-fenfluramine.</p> <p>Conclusion</p> <p>Although these results fail to support prior findings of independent associations of these polymorphisms with smoking status, our exploratory findings suggestive of gene-gene and gene-treatment interactions warrants further investigation.</p> |
| first_indexed | 2024-04-12T20:50:05Z |
| format | Article |
| id | doaj.art-3aca52b6de704e81959816bdd637efd6 |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-04-12T20:50:05Z |
| publishDate | 2007-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-3aca52b6de704e81959816bdd637efd62022-12-22T03:17:09ZengBMCBehavioral and Brain Functions1744-90812007-04-01312210.1186/1744-9081-3-22Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort studySrinouanprachan SengkeoBowen Deborah JRossing MaryTon Thanh GNWicklund KristineFarin Federico M<p>Abstract</p> <p>Background</p> <p>Genes involved in dopaminergic neurotransmission have been suggested as candidates for involvement in smoking behavior. We hypothesized that alleles associated with reduced dopaminergic neurotransmission would be more common in continuing smokers than among women who quit smoking.</p> <p>Methods</p> <p>The study included 593 women aged 26–65 years who participated in a twelve month smoking cessation trial conducted in 1993–1994. Participants were contacted three years after the trial to obtain updated smoking history and biological specimens. Seven polymorphisms were assessed in genes involved in dopamine synthesis (tyrosine hydoxylase [<it>TH</it>]), receptor activation (dopamine receptors [<it>DRD2</it>, <it>DRD3</it>, <it>DRD4</it>]), reuptake (dopamine transporter [<it>SLC6A3</it>]), and metabolism (catechol-o-methyltransferase [<it>COMT</it>]). Smoking cessation was assessed as "short-term" quitting (abstinence for the seven days before the conclusion of the trial) and "long-term" quitting (abstinence for the six months before a subsequent interview conducted several years later).</p> <p>Results</p> <p>We observed no association of any polymorphism with either short- or long-term quitting. Although some relative risk estimates were consistent with weak associations, either the direction of effect was opposite of that hypothesized, or results of the short- and long-term cessation endpoints differed. However, effect modification on smoking cessation was observed between DRD2 Taq1A and SLC6A3 VNTR polymorphisms, DRD3 Ser/Gly and d,1-fenfluramine, and DRD4 VNTR and d,1-fenfluramine.</p> <p>Conclusion</p> <p>Although these results fail to support prior findings of independent associations of these polymorphisms with smoking status, our exploratory findings suggestive of gene-gene and gene-treatment interactions warrants further investigation.</p>http://www.behavioralandbrainfunctions.com/content/3/1/22 |
| spellingShingle | Srinouanprachan Sengkeo Bowen Deborah J Rossing Mary Ton Thanh GN Wicklund Kristine Farin Federico M Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study Behavioral and Brain Functions |
| title | Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study |
| title_full | Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study |
| title_fullStr | Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study |
| title_full_unstemmed | Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study |
| title_short | Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study |
| title_sort | genetic polymorphisms in dopamine related genes and smoking cessation in women a prospective cohort study |
| url | http://www.behavioralandbrainfunctions.com/content/3/1/22 |
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