EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2018-01-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/7/1/149.full |
| _version_ | 1818909543925547008 |
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| author | Frederic Schrøder Arendrup Severine Mazaud-Guittot Bernard Jégou David Møbjerg Kristensen |
| author_facet | Frederic Schrøder Arendrup Severine Mazaud-Guittot Bernard Jégou David Møbjerg Kristensen |
| author_sort | Frederic Schrøder Arendrup |
| collection | DOAJ |
| description | Concern has been raised over chemical-induced disruption of ovary development during
fetal life resulting in long-lasting consequences only manifesting themselves much later
during adulthood. A growing body of evidence suggests that prenatal exposure to
the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore,
in this review, we discuss three recent reports that collectively indicate that prenatal
exposure in a period of 13.5 days post coitum in both rats and mouse can result in
reduced female reproductive health. The combined data show that the exposure results
in the reduction of primordial follicles, irregular menstrual cycle, premature absence of
corpus luteum, as well as reduced fertility, resembling premature ovarian insufficiency
syndrome in humans that is linked to premature menopause. This could especially affect
the Western parts of the world, where the age for childbirth is continuously being
increased and acetaminophen is recommended during pregnancy for pain and fever.
We therefore highlight an urgent need for more studies to verify these data including
both experimental and epidemiological approaches. |
| first_indexed | 2024-12-19T22:28:35Z |
| format | Article |
| id | doaj.art-3acace0efc2e44c48b984db2991de533 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-19T22:28:35Z |
| publishDate | 2018-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-3acace0efc2e44c48b984db2991de5332022-12-21T20:03:25ZengBioscientificaEndocrine Connections2049-36142049-36142018-01-017114915810.1530/EC-17-0298EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?Frederic Schrøder Arendrup0Severine Mazaud-Guittot1Bernard Jégou2David Møbjerg Kristensen3Department of Neurology, Danish Headache Center, Rigshospitalet, University of Copenhagen, DenmarkInserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, FranceInserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France; EHESP-School of Public Health, Rennes, FranceDepartment of Neurology, Danish Headache Center, Rigshospitalet, University of Copenhagen, Denmark; Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, FranceConcern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore, in this review, we discuss three recent reports that collectively indicate that prenatal exposure in a period of 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health. The combined data show that the exposure results in the reduction of primordial follicles, irregular menstrual cycle, premature absence of corpus luteum, as well as reduced fertility, resembling premature ovarian insufficiency syndrome in humans that is linked to premature menopause. This could especially affect the Western parts of the world, where the age for childbirth is continuously being increased and acetaminophen is recommended during pregnancy for pain and fever. We therefore highlight an urgent need for more studies to verify these data including both experimental and epidemiological approaches.http://www.endocrineconnections.com/content/7/1/149.fullfertilityfolliclesprimordial germ cellsacetaminophen/ paracetamoltylenoldevelopment |
| spellingShingle | Frederic Schrøder Arendrup Severine Mazaud-Guittot Bernard Jégou David Møbjerg Kristensen EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development? Endocrine Connections fertility follicles primordial germ cells acetaminophen/ paracetamol tylenol development |
| title | EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development? |
| title_full | EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development? |
| title_fullStr | EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development? |
| title_full_unstemmed | EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development? |
| title_short | EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development? |
| title_sort | edc impact is exposure during pregnancy to acetaminophen paracetamol disrupting female reproductive development |
| topic | fertility follicles primordial germ cells acetaminophen/ paracetamol tylenol development |
| url | http://www.endocrineconnections.com/content/7/1/149.full |
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