Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study
BackgroundPlenty of observational studies suggested that vitamin D concentrations were associated with psoriasis, but the causality of this relationship was elusive.ObjectiveTo investigate the causal relationship between vitamin D and psoriasis.MethodsCox proportional hazard model was used to invest...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.807344/full |
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| author | Yan Zhang Yan Zhang Danrong Jing Danrong Jing Danrong Jing Guowei Zhou Guowei Zhou Guowei Zhou Yi Xiao Yi Xiao Yi Xiao Minxue Shen Minxue Shen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Hong Liu Hong Liu Hong Liu Hong Liu Hong Liu Hong Liu |
| author_facet | Yan Zhang Yan Zhang Danrong Jing Danrong Jing Danrong Jing Guowei Zhou Guowei Zhou Guowei Zhou Yi Xiao Yi Xiao Yi Xiao Minxue Shen Minxue Shen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Hong Liu Hong Liu Hong Liu Hong Liu Hong Liu Hong Liu |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | BackgroundPlenty of observational studies suggested that vitamin D concentrations were associated with psoriasis, but the causality of this relationship was elusive.ObjectiveTo investigate the causal relationship between vitamin D and psoriasis.MethodsCox proportional hazard model was used to investigate the association between vitamin D status and psoriasis in a prospective cohort study from UK Biobank. Single nucleotide polymorphisms (SNPs) that are strongly associated with circulating 25OHD were constructed as instrumental variables in Mendelian randomization (MR) to determine the causality between vitamin D and psoriasis.ResultsDuring a median follow-up of 10.99 years, we identified 2,856 participants with incident psoriasis. The prospective cohort study demonstrated individuals with 25OHD deficiency (< 25 nmol/L) at baseline were associated with approximately 20% increased risk of incident psoriasis in different categories of sex, age, and body mass index (BMI) after adjusting for covariates. The largest effect size was observed in the obese group (BMI > 30 kg/m2), as 25OHD deficiency presented with 30% additional risk of incident psoriasis compared to those with 25OHD > 50 nmol/L (HR = 0.701; 95% CI: 0.583–0.843; p < 0.001). Additionally, 69 independent SNPs associated with circulating 25OHD level were selected for the MR analysis, and the result suggested that genetically predicted one standard deviation (SD) increment in log-transformed 25OHD was associated with 24% decreased risk of psoriasis (OR = 0.76; 95% CI: 0.60–0.98, p = 0.020).LimitationsThe association of 25OHD and severity of psoriasis could not be estimated in the current study.ConclusionThe combined prospective and MR analysis additionally provided evidence that the epidemiologically and genetically determined level of 25OHD conferred an increased risk of psoriasis. |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T20:19:02Z |
| publishDate | 2022-07-01 |
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| spelling | doaj.art-3acb48cae6bf44c2ba4d8a2c1433ce282022-12-22T02:31:36ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-07-01910.3389/fnut.2022.807344807344Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank StudyYan Zhang0Yan Zhang1Danrong Jing2Danrong Jing3Danrong Jing4Guowei Zhou5Guowei Zhou6Guowei Zhou7Yi Xiao8Yi Xiao9Yi Xiao10Minxue Shen11Minxue Shen12Xiang Chen13Xiang Chen14Xiang Chen15Xiang Chen16Xiang Chen17Xiang Chen18Hong Liu19Hong Liu20Hong Liu21Hong Liu22Hong Liu23Hong Liu24Department of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, ChinaHunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, ChinaHunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, ChinaHunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, ChinaHunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, ChinaXiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, ChinaHunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, ChinaXiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaBackgroundPlenty of observational studies suggested that vitamin D concentrations were associated with psoriasis, but the causality of this relationship was elusive.ObjectiveTo investigate the causal relationship between vitamin D and psoriasis.MethodsCox proportional hazard model was used to investigate the association between vitamin D status and psoriasis in a prospective cohort study from UK Biobank. Single nucleotide polymorphisms (SNPs) that are strongly associated with circulating 25OHD were constructed as instrumental variables in Mendelian randomization (MR) to determine the causality between vitamin D and psoriasis.ResultsDuring a median follow-up of 10.99 years, we identified 2,856 participants with incident psoriasis. The prospective cohort study demonstrated individuals with 25OHD deficiency (< 25 nmol/L) at baseline were associated with approximately 20% increased risk of incident psoriasis in different categories of sex, age, and body mass index (BMI) after adjusting for covariates. The largest effect size was observed in the obese group (BMI > 30 kg/m2), as 25OHD deficiency presented with 30% additional risk of incident psoriasis compared to those with 25OHD > 50 nmol/L (HR = 0.701; 95% CI: 0.583–0.843; p < 0.001). Additionally, 69 independent SNPs associated with circulating 25OHD level were selected for the MR analysis, and the result suggested that genetically predicted one standard deviation (SD) increment in log-transformed 25OHD was associated with 24% decreased risk of psoriasis (OR = 0.76; 95% CI: 0.60–0.98, p = 0.020).LimitationsThe association of 25OHD and severity of psoriasis could not be estimated in the current study.ConclusionThe combined prospective and MR analysis additionally provided evidence that the epidemiologically and genetically determined level of 25OHD conferred an increased risk of psoriasis.https://www.frontiersin.org/articles/10.3389/fnut.2022.807344/fullpsoriasisvitamin DcausalityMRBMI |
| spellingShingle | Yan Zhang Yan Zhang Danrong Jing Danrong Jing Danrong Jing Guowei Zhou Guowei Zhou Guowei Zhou Yi Xiao Yi Xiao Yi Xiao Minxue Shen Minxue Shen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Xiang Chen Hong Liu Hong Liu Hong Liu Hong Liu Hong Liu Hong Liu Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study Frontiers in Nutrition psoriasis vitamin D causality MR BMI |
| title | Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study |
| title_full | Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study |
| title_fullStr | Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study |
| title_full_unstemmed | Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study |
| title_short | Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study |
| title_sort | evidence of a causal relationship between vitamin d status and risk of psoriasis from the uk biobank study |
| topic | psoriasis vitamin D causality MR BMI |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.807344/full |
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