Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms
Recent developments in bioinformatics technologies have led to advances in our understanding of how oncogenic viruses such as the human papilloma virus drive cancer progression and evade the host immune system. Here, we focus our review on understanding how these emerging bioinformatics technologies...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/10/1543 |
| _version_ | 1797761563428388864 |
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| author | Elizabeth Gensterblum-Miller J. Chad Brenner |
| author_facet | Elizabeth Gensterblum-Miller J. Chad Brenner |
| author_sort | Elizabeth Gensterblum-Miller |
| collection | DOAJ |
| description | Recent developments in bioinformatics technologies have led to advances in our understanding of how oncogenic viruses such as the human papilloma virus drive cancer progression and evade the host immune system. Here, we focus our review on understanding how these emerging bioinformatics technologies influence our understanding of how human papilloma virus (HPV) drives immune escape in cancers of the head and neck, and how these new informatics approaches may be generally applicable to other virally driven cancers. Indeed, these tools enable researchers to put existing data from genome wide association studies, in which high risk alleles have been identified, in the context of our current understanding of cellular processes regulating neoantigen presentation. In the future, these new bioinformatics approaches are highly likely to influence precision medicine-based decision making for the use of immunotherapies in virally driven cancers. |
| first_indexed | 2024-03-12T19:15:58Z |
| format | Article |
| id | doaj.art-3acc87b10ad34c3fbb3c28560e74a61f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:15:58Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3acc87b10ad34c3fbb3c28560e74a61f2023-08-02T05:32:04ZengMDPI AGCancers2072-66942019-10-011110154310.3390/cancers11101543cancers11101543Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics AlgorithmsElizabeth Gensterblum-Miller0J. Chad Brenner1Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USAProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USARecent developments in bioinformatics technologies have led to advances in our understanding of how oncogenic viruses such as the human papilloma virus drive cancer progression and evade the host immune system. Here, we focus our review on understanding how these emerging bioinformatics technologies influence our understanding of how human papilloma virus (HPV) drives immune escape in cancers of the head and neck, and how these new informatics approaches may be generally applicable to other virally driven cancers. Indeed, these tools enable researchers to put existing data from genome wide association studies, in which high risk alleles have been identified, in the context of our current understanding of cellular processes regulating neoantigen presentation. In the future, these new bioinformatics approaches are highly likely to influence precision medicine-based decision making for the use of immunotherapies in virally driven cancers.https://www.mdpi.com/2072-6694/11/10/1543hnscchuman papilloma virusneoantigen bioinformatics |
| spellingShingle | Elizabeth Gensterblum-Miller J. Chad Brenner Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms Cancers hnscc human papilloma virus neoantigen bioinformatics |
| title | Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms |
| title_full | Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms |
| title_fullStr | Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms |
| title_full_unstemmed | Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms |
| title_short | Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms |
| title_sort | protecting tumors by preventing human papilloma virus antigen presentation insights from emerging bioinformatics algorithms |
| topic | hnscc human papilloma virus neoantigen bioinformatics |
| url | https://www.mdpi.com/2072-6694/11/10/1543 |
| work_keys_str_mv | AT elizabethgensterblummiller protectingtumorsbypreventinghumanpapillomavirusantigenpresentationinsightsfromemergingbioinformaticsalgorithms AT jchadbrenner protectingtumorsbypreventinghumanpapillomavirusantigenpresentationinsightsfromemergingbioinformaticsalgorithms |