Functional Implications of the Prosomeric Brain Model
Brain models present a viewpoint on the fundamental structural components of the brain and their mutual organization, generally relative to a particular concept of the brain axis. A model may be based on adult brain structure or on developmental morphogenetic aspects. Brain models usually have funct...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/3/331 |
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| author | Luis Puelles |
| author_facet | Luis Puelles |
| author_sort | Luis Puelles |
| collection | DOAJ |
| description | Brain models present a viewpoint on the fundamental structural components of the brain and their mutual organization, generally relative to a particular concept of the brain axis. A model may be based on adult brain structure or on developmental morphogenetic aspects. Brain models usually have functional implications, depending on which functional properties derive from the postulated organization. This essay examines the present scenario about brain models, emphasizing the contrast between columnar or other longitudinal models and transverse subdivisional neuromeric models. In each case, the main functional implications and apparent problems are explored and commented. Particular attention is given to the modern molecularly based ‘prosomeric model’, which postulates a set of 20 transverse prosomeres as the developmental units that serve to construct all the cerebral parts and the particular typology of many different neuronal populations within the forebrain and the hindbrain, plus a number of additional spinal cord units. These metameric developmental units (serially repeated, but with unique molecular profiles) confer to this model remarkable functional properties based mainly on its multiplicity and modularity. Many important brain functions can be decomposed into subfunctions attended to by combined sets of neuronal elements derived from different neuromeres. Each neuromere may participate in multiple functions. Most aspects related to creation of precise order in neural connections (axonal navigation and synaptogenesis) and function is due to the influence of neuromeric anteroposterior and dorsoventral positional information. Research on neuromeric functionality aspects is increasing significantly in recent times. |
| first_indexed | 2024-04-24T18:29:55Z |
| format | Article |
| id | doaj.art-3acc962843204e5ca1388a5d40d437c3 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-04-24T18:29:55Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3acc962843204e5ca1388a5d40d437c32024-03-27T13:27:58ZengMDPI AGBiomolecules2218-273X2024-03-0114333110.3390/biom14030331Functional Implications of the Prosomeric Brain ModelLuis Puelles0Department Human Anatomy and Psychobiology and IMIB-Arrixaca (Murcia Institute for Biomedical Research), University of Murcia, LAIB Building, Avenida Buenavista s/n, El Palmar, 30120 Murcia, SpainBrain models present a viewpoint on the fundamental structural components of the brain and their mutual organization, generally relative to a particular concept of the brain axis. A model may be based on adult brain structure or on developmental morphogenetic aspects. Brain models usually have functional implications, depending on which functional properties derive from the postulated organization. This essay examines the present scenario about brain models, emphasizing the contrast between columnar or other longitudinal models and transverse subdivisional neuromeric models. In each case, the main functional implications and apparent problems are explored and commented. Particular attention is given to the modern molecularly based ‘prosomeric model’, which postulates a set of 20 transverse prosomeres as the developmental units that serve to construct all the cerebral parts and the particular typology of many different neuronal populations within the forebrain and the hindbrain, plus a number of additional spinal cord units. These metameric developmental units (serially repeated, but with unique molecular profiles) confer to this model remarkable functional properties based mainly on its multiplicity and modularity. Many important brain functions can be decomposed into subfunctions attended to by combined sets of neuronal elements derived from different neuromeres. Each neuromere may participate in multiple functions. Most aspects related to creation of precise order in neural connections (axonal navigation and synaptogenesis) and function is due to the influence of neuromeric anteroposterior and dorsoventral positional information. Research on neuromeric functionality aspects is increasing significantly in recent times.https://www.mdpi.com/2218-273X/14/3/331brain modelscolumnar modelneuromeric models-synthetic modelprosomeric modelbrain functionsmodularity |
| spellingShingle | Luis Puelles Functional Implications of the Prosomeric Brain Model Biomolecules brain models columnar model neuromeric models-synthetic model prosomeric model brain functions modularity |
| title | Functional Implications of the Prosomeric Brain Model |
| title_full | Functional Implications of the Prosomeric Brain Model |
| title_fullStr | Functional Implications of the Prosomeric Brain Model |
| title_full_unstemmed | Functional Implications of the Prosomeric Brain Model |
| title_short | Functional Implications of the Prosomeric Brain Model |
| title_sort | functional implications of the prosomeric brain model |
| topic | brain models columnar model neuromeric models-synthetic model prosomeric model brain functions modularity |
| url | https://www.mdpi.com/2218-273X/14/3/331 |
| work_keys_str_mv | AT luispuelles functionalimplicationsoftheprosomericbrainmodel |