Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in <i>Apostichopus japonicus</i>
The intestinal tract is the most important location for symbiotes and pathogens, and the microbiota plays a crucial role in affecting the health of the gut and other host organs. Dysbacteriosis in the intestinal system has been proven to be significant in skin ulceration syndrome (SUS) in sea cucumb...
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13583 |
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| author | Zhen Zhang Mingshan Song Zhimeng Lv Ming Guo Chenghua Li |
| author_facet | Zhen Zhang Mingshan Song Zhimeng Lv Ming Guo Chenghua Li |
| author_sort | Zhen Zhang |
| collection | DOAJ |
| description | The intestinal tract is the most important location for symbiotes and pathogens, and the microbiota plays a crucial role in affecting the health of the gut and other host organs. Dysbacteriosis in the intestinal system has been proven to be significant in skin ulceration syndrome (SUS) in sea cucumbers. This study investigates whether the gut microbiota and lipid metabolites are relevant to the initiation and progression of SUS in a <i>Vibrio-splendidus</i>-infected sea cucumber model. The tight junction genes were downregulated and the inflammatory factor gene transcriptions were upregulated after <i>V. splendidus</i> infection in the intestinal tissue of the sea cucumber. <i>V. splendidus</i> infection modulated the gut microbiota by interacting with <i>Psychromonas macrocephali</i>, <i>Propionigenium maris</i>, <i>Bacillus cereus</i>, <i>Lutibacter flavus,</i> and <i>Hoeflea halophila</i>. Meanwhile, the metabolites of the long-chain fatty acids in the intestinal tissue, including triglycerides (TG), phosphatidylethanolamines (PE), and phosphatidylglycerols (PG), were altered after <i>V. splendidus</i> infection. <i>V. splendidus</i> engaged in positive interactions with PG and PE and negative interactions with specific TG. These results related to gut microbiota and metabolites can offer practical assistance in the identification of the inflammatory mechanisms related to SUS, and this study may serve as a reference for predicting the disease. |
| first_indexed | 2024-03-09T18:59:27Z |
| format | Article |
| id | doaj.art-3acf4b5656d9496084aadf50e70761d3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:59:27Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3acf4b5656d9496084aadf50e70761d32023-11-24T05:10:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123211358310.3390/ijms232113583Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in <i>Apostichopus japonicus</i>Zhen Zhang0Mingshan Song1Zhimeng Lv2Ming Guo3Chenghua Li4State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, ChinaThe intestinal tract is the most important location for symbiotes and pathogens, and the microbiota plays a crucial role in affecting the health of the gut and other host organs. Dysbacteriosis in the intestinal system has been proven to be significant in skin ulceration syndrome (SUS) in sea cucumbers. This study investigates whether the gut microbiota and lipid metabolites are relevant to the initiation and progression of SUS in a <i>Vibrio-splendidus</i>-infected sea cucumber model. The tight junction genes were downregulated and the inflammatory factor gene transcriptions were upregulated after <i>V. splendidus</i> infection in the intestinal tissue of the sea cucumber. <i>V. splendidus</i> infection modulated the gut microbiota by interacting with <i>Psychromonas macrocephali</i>, <i>Propionigenium maris</i>, <i>Bacillus cereus</i>, <i>Lutibacter flavus,</i> and <i>Hoeflea halophila</i>. Meanwhile, the metabolites of the long-chain fatty acids in the intestinal tissue, including triglycerides (TG), phosphatidylethanolamines (PE), and phosphatidylglycerols (PG), were altered after <i>V. splendidus</i> infection. <i>V. splendidus</i> engaged in positive interactions with PG and PE and negative interactions with specific TG. These results related to gut microbiota and metabolites can offer practical assistance in the identification of the inflammatory mechanisms related to SUS, and this study may serve as a reference for predicting the disease.https://www.mdpi.com/1422-0067/23/21/13583<i>Apostichopus japonicus</i>gut microbiotalipid metabolitesskin ulceration syndrome |
| spellingShingle | Zhen Zhang Mingshan Song Zhimeng Lv Ming Guo Chenghua Li Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in <i>Apostichopus japonicus</i> International Journal of Molecular Sciences <i>Apostichopus japonicus</i> gut microbiota lipid metabolites skin ulceration syndrome |
| title | Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in <i>Apostichopus japonicus</i> |
| title_full | Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in <i>Apostichopus japonicus</i> |
| title_fullStr | Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in <i>Apostichopus japonicus</i> |
| title_full_unstemmed | Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in <i>Apostichopus japonicus</i> |
| title_short | Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in <i>Apostichopus japonicus</i> |
| title_sort | gut microbiota mediates skin ulceration syndrome outbreak by readjusting lipid metabolism in i apostichopus japonicus i |
| topic | <i>Apostichopus japonicus</i> gut microbiota lipid metabolites skin ulceration syndrome |
| url | https://www.mdpi.com/1422-0067/23/21/13583 |
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