Effects of metformin and donepezil on the prevention of doxorubicin-induced cardiotoxicity in breast cancer: a randomized controlled trial

Effects of metformin and donepezil on the prevention of doxorubicin-induced cardiotoxicity in breast cancer: a randomized controlled trial

Abstract Doxorubicin (DOX) causes deleterious cardiotoxicity. We aimed to investigate the protective roles of metformin and donepezil against DOX-induced cardiotoxicity. In this randomized-controlled trial, 143 female breast cancer patients were enrolled. Metformin (n = 43), donepezil (n = 52), or p...

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Bibliographic Details
Main Authors: Nichanan Osataphan, Arintaya Phrommintikul, Krit Leemasawat, Areewan Somwangprasert, Nattayaporn Apaijai, Supanai Suksai, Wachiranun Sirikul, Siriluck Gunaparn, Siriporn C. Chattipakorn, Nipon Chattipakorn
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40061-4

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https://doi.org/10.1038/s41598-023-40061-4

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