Effects of metformin and donepezil on the prevention of doxorubicin-induced cardiotoxicity in breast cancer: a randomized controlled trial
Abstract Doxorubicin (DOX) causes deleterious cardiotoxicity. We aimed to investigate the protective roles of metformin and donepezil against DOX-induced cardiotoxicity. In this randomized-controlled trial, 143 female breast cancer patients were enrolled. Metformin (n = 43), donepezil (n = 52), or p...
Main Authors: | Nichanan Osataphan, Arintaya Phrommintikul, Krit Leemasawat, Areewan Somwangprasert, Nattayaporn Apaijai, Supanai Suksai, Wachiranun Sirikul, Siriluck Gunaparn, Siriporn C. Chattipakorn, Nipon Chattipakorn |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-08-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-40061-4 |
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