RASSF1A Suppression as a Potential Regulator of Mechano-Pathobiology Associated with Mammographic Density in BRCA Mutation Carriers

RASSF1A Suppression as a Potential Regulator of Mechano-Pathobiology Associated with Mammographic Density in BRCA Mutation Carriers

High mammographic density (MD) increases breast cancer (BC) risk and creates a stiff tissue environment. BC risk is also increased in <i>BRCA1/2</i> gene mutation carriers, which may be in part due to genetic disruption of the tumour suppressor gene Ras association domain family member 1...

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Bibliographic Details
Main Authors: Gina Reye, Xuan Huang, Kara L. Britt, Christoph Meinert, Tony Blick, Yannan Xu, Konstantin I. Momot, Thomas Lloyd, Jason J. Northey, Erik W. Thompson, Honor J. Hugo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
mammographic density
<i>RASSF1A</i>
<i>BRCA1/2</i> mutations
stiffness
breast cancer
Online Access:https://www.mdpi.com/2072-6694/13/13/3251

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