Exact Probability Landscapes of Stochastic Phenotype Switching in Feed-Forward Loops: Phase Diagrams of Multimodality

Exact Probability Landscapes of Stochastic Phenotype Switching in Feed-Forward Loops: Phase Diagrams of Multimodality

Feed-forward loops (FFLs) are among the most ubiquitously found motifs of reaction networks in nature. However, little is known about their stochastic behavior and the variety of network phenotypes they can exhibit. In this study, we provide full characterizations of the properties of stochastic mul...

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Bibliographic Details
Main Authors: Anna Terebus, Farid Manuchehrfar, Youfang Cao, Jie Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Genetics
Subjects:
systems biology
feed forward loop
gene regulatory network
network motif
stochastic reaction network
persistent homology
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.645640/full

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