Non-invasive fetal electrocardiography, electrohysterography and speckle-tracking echocardiography in the second trimester: study protocol of a longitudinal prospective cohort study (BEATS-study)
Abstract Background Worldwide, hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR) and preterm birth remain the leading causes of maternal and fetal pregnancy-related mortality and (long-term) morbidity. Fetal cardiac deformation changes can be the first sign of placental dysfu...
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BMC
2021-11-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-021-04265-8 |
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| author | T. J. Nichting M. W. E. Frenken D. A. A. van der Woude N. H. M. van Oostrum C. M. de Vet B. G. van Willigen J. O. E. H. van Laar M. van der Ven S. G. Oei |
| author_facet | T. J. Nichting M. W. E. Frenken D. A. A. van der Woude N. H. M. van Oostrum C. M. de Vet B. G. van Willigen J. O. E. H. van Laar M. van der Ven S. G. Oei |
| author_sort | T. J. Nichting |
| collection | DOAJ |
| description | Abstract Background Worldwide, hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR) and preterm birth remain the leading causes of maternal and fetal pregnancy-related mortality and (long-term) morbidity. Fetal cardiac deformation changes can be the first sign of placental dysfunction, which is associated with HDP, FGR and preterm birth. In addition, preterm birth is likely associated with changes in electrical activity across the uterine muscle. Therefore, fetal cardiac function and uterine activity can be used for the early detection of these complications in pregnancy. Fetal cardiac function and uterine activity can be assessed by two-dimensional speckle-tracking echocardiography (2D-STE), non-invasive fetal electrocardiography (NI-fECG), and electrohysterography (EHG). This study aims to generate reference values for 2D-STE, NI-fECG and EHG parameters during the second trimester of pregnancy and to investigate the diagnostic potential of these parameters in the early detection of HDP, FGR and preterm birth. Methods In this longitudinal prospective cohort study, eligible women will be recruited from a tertiary care hospital and a primary midwifery practice. In total, 594 initially healthy pregnant women with an uncomplicated singleton pregnancy will be included. Recordings of NI-fECG and EHG will be made weekly from 22 until 28 weeks of gestation and 2D-STE measurements will be performed 4-weekly at 16, 20, 24 and 28 weeks gestational age. Retrospectively, pregnancies complicated with pregnancy-related diseases will be excluded from the cohort. Reference values for 2D-STE, NI-fECG and EHG parameters will be assessed in uncomplicated pregnancies. After, 2D-STE, NI-fCG and EHG parameters measured during gestation in complicated pregnancies will be compared with these reference values. Discussion This will be the a large prospective study investigating new technologies that could potentially have a high impact on antepartum fetal monitoring. Trial registration Registered on 26 March 2020 in the Dutch Trial Register (NL8769) via https://www.trialregister.nl/trials and registered on 21 October 2020 to the Central Committee on Research Involving Human Subjects (NL73607.015.20) via https://www.toetsingonline.nl/to/ccmo_search.nsf/Searchform?OpenForm . |
| first_indexed | 2024-12-17T13:43:31Z |
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| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-17T13:43:31Z |
| publishDate | 2021-11-01 |
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| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-3ad4e65699fe4694937efb4d5e7d16db2022-12-21T21:46:13ZengBMCBMC Pregnancy and Childbirth1471-23932021-11-0121111110.1186/s12884-021-04265-8Non-invasive fetal electrocardiography, electrohysterography and speckle-tracking echocardiography in the second trimester: study protocol of a longitudinal prospective cohort study (BEATS-study)T. J. Nichting0M. W. E. Frenken1D. A. A. van der Woude2N. H. M. van Oostrum3C. M. de Vet4B. G. van Willigen5J. O. E. H. van Laar6M. van der Ven7S. G. Oei8Department of Gynaecology and Obstetrics, Máxima MCDepartment of Gynaecology and Obstetrics, Máxima MCDepartment of Gynaecology and Obstetrics, Máxima MCDepartment of Electrical Engineering, Eindhoven University of TechnologyDepartment of Gynaecology and Obstetrics, Máxima MCDepartment of Gynaecology and Obstetrics, Máxima MCDepartment of Gynaecology and Obstetrics, Máxima MCDepartment of Gynaecology and Obstetrics, Máxima MCDepartment of Gynaecology and Obstetrics, Máxima MCAbstract Background Worldwide, hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR) and preterm birth remain the leading causes of maternal and fetal pregnancy-related mortality and (long-term) morbidity. Fetal cardiac deformation changes can be the first sign of placental dysfunction, which is associated with HDP, FGR and preterm birth. In addition, preterm birth is likely associated with changes in electrical activity across the uterine muscle. Therefore, fetal cardiac function and uterine activity can be used for the early detection of these complications in pregnancy. Fetal cardiac function and uterine activity can be assessed by two-dimensional speckle-tracking echocardiography (2D-STE), non-invasive fetal electrocardiography (NI-fECG), and electrohysterography (EHG). This study aims to generate reference values for 2D-STE, NI-fECG and EHG parameters during the second trimester of pregnancy and to investigate the diagnostic potential of these parameters in the early detection of HDP, FGR and preterm birth. Methods In this longitudinal prospective cohort study, eligible women will be recruited from a tertiary care hospital and a primary midwifery practice. In total, 594 initially healthy pregnant women with an uncomplicated singleton pregnancy will be included. Recordings of NI-fECG and EHG will be made weekly from 22 until 28 weeks of gestation and 2D-STE measurements will be performed 4-weekly at 16, 20, 24 and 28 weeks gestational age. Retrospectively, pregnancies complicated with pregnancy-related diseases will be excluded from the cohort. Reference values for 2D-STE, NI-fECG and EHG parameters will be assessed in uncomplicated pregnancies. After, 2D-STE, NI-fCG and EHG parameters measured during gestation in complicated pregnancies will be compared with these reference values. Discussion This will be the a large prospective study investigating new technologies that could potentially have a high impact on antepartum fetal monitoring. Trial registration Registered on 26 March 2020 in the Dutch Trial Register (NL8769) via https://www.trialregister.nl/trials and registered on 21 October 2020 to the Central Committee on Research Involving Human Subjects (NL73607.015.20) via https://www.toetsingonline.nl/to/ccmo_search.nsf/Searchform?OpenForm .https://doi.org/10.1186/s12884-021-04265-8Non-invasive fetal electrocardiographyElectrohysterographySpeckle-tracking echocardiographyHypertensive disorders of pregnancyFetal growth restrictionPreterm birth |
| spellingShingle | T. J. Nichting M. W. E. Frenken D. A. A. van der Woude N. H. M. van Oostrum C. M. de Vet B. G. van Willigen J. O. E. H. van Laar M. van der Ven S. G. Oei Non-invasive fetal electrocardiography, electrohysterography and speckle-tracking echocardiography in the second trimester: study protocol of a longitudinal prospective cohort study (BEATS-study) BMC Pregnancy and Childbirth Non-invasive fetal electrocardiography Electrohysterography Speckle-tracking echocardiography Hypertensive disorders of pregnancy Fetal growth restriction Preterm birth |
| title | Non-invasive fetal electrocardiography, electrohysterography and speckle-tracking echocardiography in the second trimester: study protocol of a longitudinal prospective cohort study (BEATS-study) |
| title_full | Non-invasive fetal electrocardiography, electrohysterography and speckle-tracking echocardiography in the second trimester: study protocol of a longitudinal prospective cohort study (BEATS-study) |
| title_fullStr | Non-invasive fetal electrocardiography, electrohysterography and speckle-tracking echocardiography in the second trimester: study protocol of a longitudinal prospective cohort study (BEATS-study) |
| title_full_unstemmed | Non-invasive fetal electrocardiography, electrohysterography and speckle-tracking echocardiography in the second trimester: study protocol of a longitudinal prospective cohort study (BEATS-study) |
| title_short | Non-invasive fetal electrocardiography, electrohysterography and speckle-tracking echocardiography in the second trimester: study protocol of a longitudinal prospective cohort study (BEATS-study) |
| title_sort | non invasive fetal electrocardiography electrohysterography and speckle tracking echocardiography in the second trimester study protocol of a longitudinal prospective cohort study beats study |
| topic | Non-invasive fetal electrocardiography Electrohysterography Speckle-tracking echocardiography Hypertensive disorders of pregnancy Fetal growth restriction Preterm birth |
| url | https://doi.org/10.1186/s12884-021-04265-8 |
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