Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians
Sepsis is a life-threatening condition caused by a dysregulated host response to an invading pathogen such as multidrug-resistant bacteria. Despite recent advancements, sepsis is a leading cause of morbidity and mortality, resulting in a significant global impact and burden. This condition affects a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/6/1682 |
| _version_ | 1827736013694304256 |
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| author | Inês Vasconcelos Tiago Santos |
| author_facet | Inês Vasconcelos Tiago Santos |
| author_sort | Inês Vasconcelos |
| collection | DOAJ |
| description | Sepsis is a life-threatening condition caused by a dysregulated host response to an invading pathogen such as multidrug-resistant bacteria. Despite recent advancements, sepsis is a leading cause of morbidity and mortality, resulting in a significant global impact and burden. This condition affects all age groups, with clinical outcomes mainly depending on a timely diagnosis and appropriate early therapeutic intervention. Because of the unique features of nanosized systems, there is a growing interest in developing and designing novel solutions. Nanoscale-engineered materials allow a targeted and controlled release of bioactive agents, resulting in improved efficacy with minimal side effects. Additionally, nanoparticle-based sensors provide a quicker and more reliable alternative to conventional diagnostic methods for identifying infection and organ dysfunction. Despite recent advancements, fundamental nanotechnology principles are often presented in technical formats that presuppose advanced chemistry, physics, and engineering knowledge. Consequently, clinicians may not grasp the underlying science, hindering interdisciplinary collaborations and successful translation from bench to bedside. In this review, we abridge some of the most recent and most promising nanotechnology-based solutions for sepsis diagnosis and management using an intelligible format to stimulate a seamless collaboration between engineers, scientists, and clinicians. |
| first_indexed | 2024-03-11T02:02:58Z |
| format | Article |
| id | doaj.art-3ad5b5718aec411aa48c9257f66bd38a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T02:02:58Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3ad5b5718aec411aa48c9257f66bd38a2023-11-18T12:04:58ZengMDPI AGPharmaceutics1999-49232023-06-01156168210.3390/pharmaceutics15061682Nanotechnology Applications in Sepsis: Essential Knowledge for CliniciansInês Vasconcelos0Tiago Santos1School of Medicine, University of Minho, 4710-057 Braga, PortugalSchool of Medicine, University of Minho, 4710-057 Braga, PortugalSepsis is a life-threatening condition caused by a dysregulated host response to an invading pathogen such as multidrug-resistant bacteria. Despite recent advancements, sepsis is a leading cause of morbidity and mortality, resulting in a significant global impact and burden. This condition affects all age groups, with clinical outcomes mainly depending on a timely diagnosis and appropriate early therapeutic intervention. Because of the unique features of nanosized systems, there is a growing interest in developing and designing novel solutions. Nanoscale-engineered materials allow a targeted and controlled release of bioactive agents, resulting in improved efficacy with minimal side effects. Additionally, nanoparticle-based sensors provide a quicker and more reliable alternative to conventional diagnostic methods for identifying infection and organ dysfunction. Despite recent advancements, fundamental nanotechnology principles are often presented in technical formats that presuppose advanced chemistry, physics, and engineering knowledge. Consequently, clinicians may not grasp the underlying science, hindering interdisciplinary collaborations and successful translation from bench to bedside. In this review, we abridge some of the most recent and most promising nanotechnology-based solutions for sepsis diagnosis and management using an intelligible format to stimulate a seamless collaboration between engineers, scientists, and clinicians.https://www.mdpi.com/1999-4923/15/6/1682sepsisdiagnostictreatmentdrug deliverynanomedicinenanotechnology |
| spellingShingle | Inês Vasconcelos Tiago Santos Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians Pharmaceutics sepsis diagnostic treatment drug delivery nanomedicine nanotechnology |
| title | Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians |
| title_full | Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians |
| title_fullStr | Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians |
| title_full_unstemmed | Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians |
| title_short | Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians |
| title_sort | nanotechnology applications in sepsis essential knowledge for clinicians |
| topic | sepsis diagnostic treatment drug delivery nanomedicine nanotechnology |
| url | https://www.mdpi.com/1999-4923/15/6/1682 |
| work_keys_str_mv | AT inesvasconcelos nanotechnologyapplicationsinsepsisessentialknowledgeforclinicians AT tiagosantos nanotechnologyapplicationsinsepsisessentialknowledgeforclinicians |