Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies

Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies

Abstract Background Since the onset of the SARS-CoV-2 pandemic, bioinformatic analyses have been performed to understand the nucleotide and synonymous codon usage features and mutational patterns of the virus. However, comparatively few have attempted to perform such analyses on a considerably large...

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Bibliographic Details
Main Authors: Sarah E. Fumagalli, Nigam H. Padhiar, Douglas Meyer, Upendra Katneni, Haim Bar, Michael DiCuccio, Anton A. Komar, Chava Kimchi-Sarfaty
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Virology Journal
Subjects:
SARS-CoV-2
Nucleotide usage
Codon usage bias
Relative synonymous codon usage
Codon adaptation index and dN/dS
Online Access:https://doi.org/10.1186/s12985-023-01982-8

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