Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol [version 1; peer review: 2 approved]
Introduction: Prematurity (birth before 37+0 weeks’ gestation) is associated with wide-ranging neurodevelopmental impairment. Prognosis among moderate to late (32+0 to <37+0 weeks’ gestation) preterm infants (MLPT) is better compared to their counterparts born very preterm (<32+0 weeks’ gest...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2021-05-01
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| Series: | Gates Open Research |
| Online Access: | https://gatesopenresearch.org/articles/5-78/v1 |
| _version_ | 1818406931396558848 |
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| author | Josephine Agyeman-Duah Stephen Kennedy Frances O'Brien Giancarlo Natalucci |
| author_facet | Josephine Agyeman-Duah Stephen Kennedy Frances O'Brien Giancarlo Natalucci |
| author_sort | Josephine Agyeman-Duah |
| collection | DOAJ |
| description | Introduction: Prematurity (birth before 37+0 weeks’ gestation) is associated with wide-ranging neurodevelopmental impairment. Prognosis among moderate to late (32+0 to <37+0 weeks’ gestation) preterm infants (MLPT) is better compared to their counterparts born very preterm (<32+0 weeks’ gestation). However the risk of developmental impairment among MLPT, who make up about 84% of all preterm infants, is 2-3 times higher when compared to infants born at term. Early interventions have aimed to improve outcomes in preterm infants generally, but there are limited data on their need and effect in MLPT specifically. Prioritising research, long-term follow-up and early interventions targeted at ameliorating the impact of preterm birth among MLPT is required. Objectives: To conduct a systematic review of the type of early childhood interventions (from birth until 4 years of age) offered to MLPT children and to evaluate their impact on neurodevelopmental outcomes (cognitive, neurobehavioural and motor) as assessed in these children during childhood (until 18 years of age). Methods and analysis: A systematic literature search in Web of Science, Medline Ovid, PsycINFO, CINAHL and EMBASE will be conducted. Data on MLPT children receiving developmental interventions until the age of 4 years will be evaluated. Interventions may involve parents or primary caregivers. Primary outcomes are cognitive, neurobehavioural and motor development as measured from birth until the age of 18 years. The Cochrane Risk of Bias Assessment Tool will be used to evaluate the methodological quality of randomised controlled trials (RCTs) included in the review and will be graded as low, high or unclear risk of bias. The quality of non-RCTs will be evaluated with the Newcastle-Ottawa Scale. The quality of evidence for each outcome will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation Approach. Publication and reporting bias will be assessed using Egger’s test and funnel plots respectively. |
| first_indexed | 2024-12-14T09:19:47Z |
| format | Article |
| id | doaj.art-3ad8735ddad9492bb51a8138ae027ffc |
| institution | Directory Open Access Journal |
| issn | 2572-4754 |
| language | English |
| last_indexed | 2024-12-14T09:19:47Z |
| publishDate | 2021-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | Gates Open Research |
| spelling | doaj.art-3ad8735ddad9492bb51a8138ae027ffc2022-12-21T23:08:20ZengF1000 Research LtdGates Open Research2572-47542021-05-01510.12688/gatesopenres.13246.114480Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol [version 1; peer review: 2 approved]Josephine Agyeman-Duah0Stephen Kennedy1Frances O'Brien2Giancarlo Natalucci3Nuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, UKNuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, UKNewborn Care Unit, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UKLarsson-Rosenquist Foundation Center for Neurodevelopment, Growth and Nutrition of the Newborn, Department of Neonatology, University of Zurich and University Hopsital Zurich, Frauenklinikstrasse 10, CH-8091 Zürich, SwitzerlandIntroduction: Prematurity (birth before 37+0 weeks’ gestation) is associated with wide-ranging neurodevelopmental impairment. Prognosis among moderate to late (32+0 to <37+0 weeks’ gestation) preterm infants (MLPT) is better compared to their counterparts born very preterm (<32+0 weeks’ gestation). However the risk of developmental impairment among MLPT, who make up about 84% of all preterm infants, is 2-3 times higher when compared to infants born at term. Early interventions have aimed to improve outcomes in preterm infants generally, but there are limited data on their need and effect in MLPT specifically. Prioritising research, long-term follow-up and early interventions targeted at ameliorating the impact of preterm birth among MLPT is required. Objectives: To conduct a systematic review of the type of early childhood interventions (from birth until 4 years of age) offered to MLPT children and to evaluate their impact on neurodevelopmental outcomes (cognitive, neurobehavioural and motor) as assessed in these children during childhood (until 18 years of age). Methods and analysis: A systematic literature search in Web of Science, Medline Ovid, PsycINFO, CINAHL and EMBASE will be conducted. Data on MLPT children receiving developmental interventions until the age of 4 years will be evaluated. Interventions may involve parents or primary caregivers. Primary outcomes are cognitive, neurobehavioural and motor development as measured from birth until the age of 18 years. The Cochrane Risk of Bias Assessment Tool will be used to evaluate the methodological quality of randomised controlled trials (RCTs) included in the review and will be graded as low, high or unclear risk of bias. The quality of non-RCTs will be evaluated with the Newcastle-Ottawa Scale. The quality of evidence for each outcome will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation Approach. Publication and reporting bias will be assessed using Egger’s test and funnel plots respectively.https://gatesopenresearch.org/articles/5-78/v1 |
| spellingShingle | Josephine Agyeman-Duah Stephen Kennedy Frances O'Brien Giancarlo Natalucci Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol [version 1; peer review: 2 approved] Gates Open Research |
| title | Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol [version 1; peer review: 2 approved] |
| title_full | Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol [version 1; peer review: 2 approved] |
| title_fullStr | Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol [version 1; peer review: 2 approved] |
| title_full_unstemmed | Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol [version 1; peer review: 2 approved] |
| title_short | Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol [version 1; peer review: 2 approved] |
| title_sort | interventions to improve neurodevelopmental outcomes of children born moderate to late preterm a systematic review protocol version 1 peer review 2 approved |
| url | https://gatesopenresearch.org/articles/5-78/v1 |
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