Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults
Inositol-stabilized arginine silicate (ASI) is an ergogenic aid that upregulates nitric oxide. Acute ASI supplementation improves working memory and processing speed in young adults but there is a lack of data examining other cognitive tasks. Therefore, the purpose of this study was to examine acute...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/12/4272 |
| _version_ | 1797501832249999360 |
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| author | Joshua L. Gills Anthony Campitelli Megan Jones Sally Paulson Jennifer Rae Myers Erica N. Madero Jordan M. Glenn James Komorowski Michelle Gray |
| author_facet | Joshua L. Gills Anthony Campitelli Megan Jones Sally Paulson Jennifer Rae Myers Erica N. Madero Jordan M. Glenn James Komorowski Michelle Gray |
| author_sort | Joshua L. Gills |
| collection | DOAJ |
| description | Inositol-stabilized arginine silicate (ASI) is an ergogenic aid that upregulates nitric oxide. Acute ASI supplementation improves working memory and processing speed in young adults but there is a lack of data examining other cognitive tasks. Therefore, the purpose of this study was to examine acute ASI effects on young healthy adults by assessing multiple cognitive domains. Nineteen young adults (20.9 ± 3.2 years) completed this randomized, double-blind, crossover study consuming ASI (1.5 g ASI + 12 g dextrose) and placebo (12 g dextrose). The participants completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and two digital cognitive assessments before consuming the supplement and then completed the same battery of tests 60 min post-supplementation. Repeated measures ANOVA demonstrated that ASI consumption significantly improved total RBANS and immediate memory scores compared to the placebo (<i>p</i> < 0.05). However, no significant differences were displayed between trials for other cognitive domains (<i>p</i> > 0.05). Acute ASI ingestion increased overall RBANS scores and immediate memory scores in young adults. More research is needed to examine the acute effects of ASI on other domains of cognition, in older populations, and its long-term effects on cognition. |
| first_indexed | 2024-03-10T03:24:17Z |
| format | Article |
| id | doaj.art-3ad9b4eb179544d999d934764241eb25 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:24:17Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3ad9b4eb179544d999d934764241eb252023-11-23T09:55:22ZengMDPI AGNutrients2072-66432021-11-011312427210.3390/nu13124272Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy AdultsJoshua L. Gills0Anthony Campitelli1Megan Jones2Sally Paulson3Jennifer Rae Myers4Erica N. Madero5Jordan M. Glenn6James Komorowski7Michelle Gray8Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, AR 72701, USADepartment of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, AR 72701, USADepartment of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, AR 72701, USASt. Elizabeth Healthcare, Edgewood, KY 41017, USANeurotrack Technologies, Inc., Redwood City, CA 94063, USANeurotrack Technologies, Inc., Redwood City, CA 94063, USANeurotrack Technologies, Inc., Redwood City, CA 94063, USAJDS Therapeutics LLC., Harrison, NY 10528, USADepartment of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, AR 72701, USAInositol-stabilized arginine silicate (ASI) is an ergogenic aid that upregulates nitric oxide. Acute ASI supplementation improves working memory and processing speed in young adults but there is a lack of data examining other cognitive tasks. Therefore, the purpose of this study was to examine acute ASI effects on young healthy adults by assessing multiple cognitive domains. Nineteen young adults (20.9 ± 3.2 years) completed this randomized, double-blind, crossover study consuming ASI (1.5 g ASI + 12 g dextrose) and placebo (12 g dextrose). The participants completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and two digital cognitive assessments before consuming the supplement and then completed the same battery of tests 60 min post-supplementation. Repeated measures ANOVA demonstrated that ASI consumption significantly improved total RBANS and immediate memory scores compared to the placebo (<i>p</i> < 0.05). However, no significant differences were displayed between trials for other cognitive domains (<i>p</i> > 0.05). Acute ASI ingestion increased overall RBANS scores and immediate memory scores in young adults. More research is needed to examine the acute effects of ASI on other domains of cognition, in older populations, and its long-term effects on cognition.https://www.mdpi.com/2072-6643/13/12/4272inositol-stabilized arginine silicatecognitionnitric oxide |
| spellingShingle | Joshua L. Gills Anthony Campitelli Megan Jones Sally Paulson Jennifer Rae Myers Erica N. Madero Jordan M. Glenn James Komorowski Michelle Gray Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults Nutrients inositol-stabilized arginine silicate cognition nitric oxide |
| title | Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults |
| title_full | Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults |
| title_fullStr | Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults |
| title_full_unstemmed | Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults |
| title_short | Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults |
| title_sort | acute inositol stabilized arginine silicate improves cognitive outcomes in healthy adults |
| topic | inositol-stabilized arginine silicate cognition nitric oxide |
| url | https://www.mdpi.com/2072-6643/13/12/4272 |
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