Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study
Abstract Background Allergic rhinitis (AR) is a major non‐communicable disease that affects the health‐related quality of life (HRQoL) of patients. However, data on HRQoL and symptom control in AR patients with comorbid asthma (AR + asthma) are lacking. Methods In this multicentre, cross‐sectional s...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.12209 |
| _version_ | 1797895131922169856 |
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| author | Subhabrata Moitra Marzia Simoni Sandra Baldacci Sara Maio Anna Angino Patrizia Silvi Giovanni Viegi Stefania La Grutta Franco Ruggiero Gianni Bedini Francesca Natali Lorenzo Cecchi Uwe Berger Maria Prentovic Amir Gamil Nour Baïz Michel Thibaudon Samuel Monnier Davide Caimmi Luciana K. Tanno Pascal Demoly Simone Orlandini Isabella Annesi‐Maesano |
| author_facet | Subhabrata Moitra Marzia Simoni Sandra Baldacci Sara Maio Anna Angino Patrizia Silvi Giovanni Viegi Stefania La Grutta Franco Ruggiero Gianni Bedini Francesca Natali Lorenzo Cecchi Uwe Berger Maria Prentovic Amir Gamil Nour Baïz Michel Thibaudon Samuel Monnier Davide Caimmi Luciana K. Tanno Pascal Demoly Simone Orlandini Isabella Annesi‐Maesano |
| author_sort | Subhabrata Moitra |
| collection | DOAJ |
| description | Abstract Background Allergic rhinitis (AR) is a major non‐communicable disease that affects the health‐related quality of life (HRQoL) of patients. However, data on HRQoL and symptom control in AR patients with comorbid asthma (AR + asthma) are lacking. Methods In this multicentre, cross‐sectional study, patients with AR were screened and administered questionnaires of demographic characteristics and health conditions (symptoms/diagnosis of AR and asthma, disease severity level, and allergic conditions). HRQoL was assessed using a modified version of the RHINASTHMA questionnaire (30, ‘not at all bothered’ ‐ 150 ‘very much bothered’) and symptom control was evaluated by a modified version of the Control of Allergic Rhinitis/Asthma Test (CARAT) (0, ‘no control’ ‐ 30, ‘very high control’). Results Out of 643 patients with AR, 500 (78%) had asthma as a comorbidity, and 54% had moderate‐severe intermittent AR, followed by moderate‐severe persistent AR (34%). Compared to the patients with AR alone, patients with AR + asthma had significantly higher RHINASTHMA (e.g., median RHINASTHMA‐total score 48.5 vs. 84, respectively) and a significantly lower CARAT score (median CARAT‐total score 23 vs. 16.5, respectively). Upon stratifying asthma based on severity, AR patients with severe persistent asthma had worse HRQoL and control than those with mild persistent asthma. The association was significantly higher among non‐obese participants compared to obese ones, with RHINASTHMA‐upper symptoms score but not with CARAT. Conclusions Our observation of poorer HRQoL and symptoms control in AR patients with comorbid asthma supports the importance of a comprehensive approach for the management of AR in case of a comorbid allergic condition. |
| first_indexed | 2024-04-10T07:20:30Z |
| format | Article |
| id | doaj.art-3adc0b0d9a78412797fc66d15e988155 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-04-10T07:20:30Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-3adc0b0d9a78412797fc66d15e9881552023-02-24T10:01:15ZengWileyClinical and Translational Allergy2045-70222023-02-01132n/an/a10.1002/clt2.12209Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European studySubhabrata Moitra0Marzia Simoni1Sandra Baldacci2Sara Maio3Anna Angino4Patrizia Silvi5Giovanni Viegi6Stefania La Grutta7Franco Ruggiero8Gianni Bedini9Francesca Natali10Lorenzo Cecchi11Uwe Berger12Maria Prentovic13Amir Gamil14Nour Baïz15Michel Thibaudon16Samuel Monnier17Davide Caimmi18Luciana K. Tanno19Pascal Demoly20Simone Orlandini21Isabella Annesi‐Maesano22Division of Pulmonary Medicine & Alberta Respiratory Centre Department of Medicine University of Alberta Edmonton Alberta CanadaPulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology (IFC) Pisa ItalyPulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology (IFC) Pisa ItalyPulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology (IFC) Pisa ItalyPulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology (IFC) Pisa ItalyPulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology (IFC) Pisa ItalyPulmonary Environmental Epidemiology Unit CNR Institute of Clinical Physiology (IFC) Pisa ItalyCNR Institute of Translational Pharmacology (IFT) Palermo ItalyDepartment of Biology University of Pisa Pisa ItalyDepartment of Biology University of Pisa Pisa ItalyDepartment of Agrifood Production and Environmental Sciences University of Florence Florence ItalyCentre of Bioclimatology University of Florence Florence ItalyResearch Unit Aerobiology and Pollen Information Department of Oto‐Rhino‐Laryngology Medical University of Vienna Vienna AustriaResearch Unit Aerobiology and Pollen Information Department of Oto‐Rhino‐Laryngology Medical University of Vienna Vienna AustriaInstitut Desbrest of Epidemiology and Santé Publique INSERM & Montpellier University Montpellier FranceInstitut Desbrest of Epidemiology and Santé Publique INSERM & Montpellier University Montpellier FranceReseau National de Surveillance Aerobiologique (RNSA) Brussieu FranceReseau National de Surveillance Aerobiologique (RNSA) Brussieu FranceInstitut Desbrest of Epidemiology and Santé Publique INSERM & Montpellier University Montpellier FranceInstitut Desbrest of Epidemiology and Santé Publique INSERM & Montpellier University Montpellier FranceInstitut Desbrest of Epidemiology and Santé Publique INSERM & Montpellier University Montpellier FranceDepartment of Agrifood Production and Environmental Sciences University of Florence Florence ItalyInstitut Desbrest of Epidemiology and Santé Publique INSERM & Montpellier University Montpellier FranceAbstract Background Allergic rhinitis (AR) is a major non‐communicable disease that affects the health‐related quality of life (HRQoL) of patients. However, data on HRQoL and symptom control in AR patients with comorbid asthma (AR + asthma) are lacking. Methods In this multicentre, cross‐sectional study, patients with AR were screened and administered questionnaires of demographic characteristics and health conditions (symptoms/diagnosis of AR and asthma, disease severity level, and allergic conditions). HRQoL was assessed using a modified version of the RHINASTHMA questionnaire (30, ‘not at all bothered’ ‐ 150 ‘very much bothered’) and symptom control was evaluated by a modified version of the Control of Allergic Rhinitis/Asthma Test (CARAT) (0, ‘no control’ ‐ 30, ‘very high control’). Results Out of 643 patients with AR, 500 (78%) had asthma as a comorbidity, and 54% had moderate‐severe intermittent AR, followed by moderate‐severe persistent AR (34%). Compared to the patients with AR alone, patients with AR + asthma had significantly higher RHINASTHMA (e.g., median RHINASTHMA‐total score 48.5 vs. 84, respectively) and a significantly lower CARAT score (median CARAT‐total score 23 vs. 16.5, respectively). Upon stratifying asthma based on severity, AR patients with severe persistent asthma had worse HRQoL and control than those with mild persistent asthma. The association was significantly higher among non‐obese participants compared to obese ones, with RHINASTHMA‐upper symptoms score but not with CARAT. Conclusions Our observation of poorer HRQoL and symptoms control in AR patients with comorbid asthma supports the importance of a comprehensive approach for the management of AR in case of a comorbid allergic condition.https://doi.org/10.1002/clt2.12209allergy treatmentCARATfood allergypollenRHINASTHMArhinitis |
| spellingShingle | Subhabrata Moitra Marzia Simoni Sandra Baldacci Sara Maio Anna Angino Patrizia Silvi Giovanni Viegi Stefania La Grutta Franco Ruggiero Gianni Bedini Francesca Natali Lorenzo Cecchi Uwe Berger Maria Prentovic Amir Gamil Nour Baïz Michel Thibaudon Samuel Monnier Davide Caimmi Luciana K. Tanno Pascal Demoly Simone Orlandini Isabella Annesi‐Maesano Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study Clinical and Translational Allergy allergy treatment CARAT food allergy pollen RHINASTHMA rhinitis |
| title | Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study |
| title_full | Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study |
| title_fullStr | Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study |
| title_full_unstemmed | Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study |
| title_short | Symptom control and health‐related quality of life in allergic rhinitis with and without comorbid asthma: A multicentre European study |
| title_sort | symptom control and health related quality of life in allergic rhinitis with and without comorbid asthma a multicentre european study |
| topic | allergy treatment CARAT food allergy pollen RHINASTHMA rhinitis |
| url | https://doi.org/10.1002/clt2.12209 |
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