<i>Achromobacter</i> spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients
<i>Achromobacter</i> is an opportunistic pathogen that mainly causes chronic lung infections in cystic fibrosis (CF) patients and is associated with increased mortality. Little is known about <i>Achromobacter</i> spp. in the lung transplant recipient (LTXr) population. We aim...
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MDPI AG
2022-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/2/181 |
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| author | Cornelia Geisler Crone Omid Rezahosseini Hans Henrik Lawaetz Schultz Tavs Qvist Helle Krogh Johansen Susanne Dam Nielsen Michael Perch |
| author_facet | Cornelia Geisler Crone Omid Rezahosseini Hans Henrik Lawaetz Schultz Tavs Qvist Helle Krogh Johansen Susanne Dam Nielsen Michael Perch |
| author_sort | Cornelia Geisler Crone |
| collection | DOAJ |
| description | <i>Achromobacter</i> is an opportunistic pathogen that mainly causes chronic lung infections in cystic fibrosis (CF) patients and is associated with increased mortality. Little is known about <i>Achromobacter</i> spp. in the lung transplant recipient (LTXr) population. We aimed at describing rates of <i>Achromobacter</i> spp. infection in LTXr prior to, in relation to, and after transplantation, as well as all-cause mortality proportion in infected and uninfected LTXr. We included 288 adult LTXr who underwent lung transplantation (LTX) between <span style="font-variant: small-caps;">1</span> January 2010 and 31 December 2019 in Denmark. Bronchoalveolar lavage was performed at regular intervals starting two weeks after transplantation. Positive cultures of <i>Achromobacter</i> spp. were identified in nationwide microbiology registries, and infections were categorized as persistent or transient, according to the proportion of positive cultures. A total of 11 of the 288 LTXr had transient (<i>n</i> = 7) or persistent (<i>n</i> = 4) <i>Achromobacter</i> spp. infection after LTX; CF was the underlying disease in 9 out of 11 LTXr. Three out of the four patients, with persistent infection after LTX, also had persistent infection before LTX. The cumulative incidence of the first episode of infection one year after LTX was 3.8% (95% CI: 1.6–6.0). The incidence rates of transient and persistent infection in the first year after LTX were 27 (12–53) and 15 (5–37) per 1000 person-years of follow-up, respectively. The all-cause mortality proportion one year after LTX was 27% in the <i>Achromobacter</i> spp. infected patients and 12% in the uninfected patients (<i>p</i> = 0.114). <i>Achromobacter</i> spp. mainly affected LTXr with CF as the underlying disease and was rare in non-CF LTXr. Larger studies are needed to assess long-term outcomes of <i>Achromobacter</i> spp. in LTXr. |
| first_indexed | 2024-03-09T21:16:45Z |
| format | Article |
| id | doaj.art-3add99c2a2e5456d9498fbc11e960b18 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T21:16:45Z |
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| spelling | doaj.art-3add99c2a2e5456d9498fbc11e960b182023-11-23T21:31:37ZengMDPI AGPathogens2076-08172022-01-0111218110.3390/pathogens11020181<i>Achromobacter</i> spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant RecipientsCornelia Geisler Crone0Omid Rezahosseini1Hans Henrik Lawaetz Schultz2Tavs Qvist3Helle Krogh Johansen4Susanne Dam Nielsen5Michael Perch6Centre of Excellence for Health, Immunity and Infections (CHIP), Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Cardiology, Section for Lung Transplantation, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Cardiology, Section for Lung Transplantation, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark<i>Achromobacter</i> is an opportunistic pathogen that mainly causes chronic lung infections in cystic fibrosis (CF) patients and is associated with increased mortality. Little is known about <i>Achromobacter</i> spp. in the lung transplant recipient (LTXr) population. We aimed at describing rates of <i>Achromobacter</i> spp. infection in LTXr prior to, in relation to, and after transplantation, as well as all-cause mortality proportion in infected and uninfected LTXr. We included 288 adult LTXr who underwent lung transplantation (LTX) between <span style="font-variant: small-caps;">1</span> January 2010 and 31 December 2019 in Denmark. Bronchoalveolar lavage was performed at regular intervals starting two weeks after transplantation. Positive cultures of <i>Achromobacter</i> spp. were identified in nationwide microbiology registries, and infections were categorized as persistent or transient, according to the proportion of positive cultures. A total of 11 of the 288 LTXr had transient (<i>n</i> = 7) or persistent (<i>n</i> = 4) <i>Achromobacter</i> spp. infection after LTX; CF was the underlying disease in 9 out of 11 LTXr. Three out of the four patients, with persistent infection after LTX, also had persistent infection before LTX. The cumulative incidence of the first episode of infection one year after LTX was 3.8% (95% CI: 1.6–6.0). The incidence rates of transient and persistent infection in the first year after LTX were 27 (12–53) and 15 (5–37) per 1000 person-years of follow-up, respectively. The all-cause mortality proportion one year after LTX was 27% in the <i>Achromobacter</i> spp. infected patients and 12% in the uninfected patients (<i>p</i> = 0.114). <i>Achromobacter</i> spp. mainly affected LTXr with CF as the underlying disease and was rare in non-CF LTXr. Larger studies are needed to assess long-term outcomes of <i>Achromobacter</i> spp. in LTXr.https://www.mdpi.com/2076-0817/11/2/181<i>Achromobacter</i>lung transplantationsolid organ transplantationcystic fibrosisincidencemortality |
| spellingShingle | Cornelia Geisler Crone Omid Rezahosseini Hans Henrik Lawaetz Schultz Tavs Qvist Helle Krogh Johansen Susanne Dam Nielsen Michael Perch <i>Achromobacter</i> spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients Pathogens <i>Achromobacter</i> lung transplantation solid organ transplantation cystic fibrosis incidence mortality |
| title | <i>Achromobacter</i> spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients |
| title_full | <i>Achromobacter</i> spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients |
| title_fullStr | <i>Achromobacter</i> spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients |
| title_full_unstemmed | <i>Achromobacter</i> spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients |
| title_short | <i>Achromobacter</i> spp. in a Cohort of Non-Selected Pre- and Post-Lung Transplant Recipients |
| title_sort | i achromobacter i spp in a cohort of non selected pre and post lung transplant recipients |
| topic | <i>Achromobacter</i> lung transplantation solid organ transplantation cystic fibrosis incidence mortality |
| url | https://www.mdpi.com/2076-0817/11/2/181 |
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