Comparison of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 for the treatment of extragenital warts in pediatric age group (5–18 years)
Introduction: Warts are benign skin growths caused by human papillomavirus. Traditional methods of treatment usually include destructive modalities which are painful and scar-forming. Such modalities have disadvantage of recurrence. Consequently, immunotherapy is introduced to overcome these problem...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Indian Journal of Paediatric Dermatology |
| Subjects: | |
| Online Access: | http://www.ijpd.in/article.asp?issn=2319-7250;year=2023;volume=24;issue=2;spage=136;epage=143;aulast=Ahmed |
| _version_ | 1797649286316425216 |
|---|---|
| author | Jafir Ahmed Ramesh Kumar Kushwaha Avinash Sharma Morish Agarwal Neha Sharma Suresh Kumar Jain |
| author_facet | Jafir Ahmed Ramesh Kumar Kushwaha Avinash Sharma Morish Agarwal Neha Sharma Suresh Kumar Jain |
| author_sort | Jafir Ahmed |
| collection | DOAJ |
| description | Introduction: Warts are benign skin growths caused by human papillomavirus. Traditional methods of treatment usually include destructive modalities which are painful and scar-forming. Such modalities have disadvantage of recurrence. Consequently, immunotherapy is introduced to overcome these problems. Aims and Objectives: To study the comparative efficacy of intralesional measles, mumps, and rubella (MMR) vaccine with intralesional Vitamin D3 for the treatment of extragenital warts in the pediatric age group (5–18 years). Materials and Methods: Seventy-two immunocompetent patients aged between 5 and 18 years with multiple extragenital warts (2 or more) were enrolled and divided randomly into two groups (Group A and Group B). Group A and Group B received intralesional MMR vaccine and Vitamin D3, respectively, in the largest wart present. The injections were repeated every 2 weeks for a maximum of four injections. Results: Complete response (CR) in injected warts in Group A is seen in 25 (83.3%) patients, partial response (PR) in 3 (10%), and no or inadequate response (NR) in 2 (6.67%) patients. CR is seen in 23 (76.66%) patients of Group B, PR in 4 (13.33%) and no or NR in 3 (10%) patients. CR in distant warts in 22 (73.33%) patients in Group A and 20 (66.66) patients in Group B. Conclusion: Both MMR vaccine and Vitamin D3 are safe, efficacious, and less traumatic to the patients for multiple warts in comparison with destructive modalities. |
| first_indexed | 2024-03-11T15:44:59Z |
| format | Article |
| id | doaj.art-3ade1ce2f0ee4b5e9018459c4dbc3848 |
| institution | Directory Open Access Journal |
| issn | 2319-7250 |
| language | English |
| last_indexed | 2024-03-11T15:44:59Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Paediatric Dermatology |
| spelling | doaj.art-3ade1ce2f0ee4b5e9018459c4dbc38482023-10-26T06:49:56ZengWolters Kluwer Medknow PublicationsIndian Journal of Paediatric Dermatology2319-72502023-01-0124213614310.4103/ijpd.ijpd_61_22Comparison of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 for the treatment of extragenital warts in pediatric age group (5–18 years)Jafir AhmedRamesh Kumar KushwahaAvinash SharmaMorish AgarwalNeha SharmaSuresh Kumar JainIntroduction: Warts are benign skin growths caused by human papillomavirus. Traditional methods of treatment usually include destructive modalities which are painful and scar-forming. Such modalities have disadvantage of recurrence. Consequently, immunotherapy is introduced to overcome these problems. Aims and Objectives: To study the comparative efficacy of intralesional measles, mumps, and rubella (MMR) vaccine with intralesional Vitamin D3 for the treatment of extragenital warts in the pediatric age group (5–18 years). Materials and Methods: Seventy-two immunocompetent patients aged between 5 and 18 years with multiple extragenital warts (2 or more) were enrolled and divided randomly into two groups (Group A and Group B). Group A and Group B received intralesional MMR vaccine and Vitamin D3, respectively, in the largest wart present. The injections were repeated every 2 weeks for a maximum of four injections. Results: Complete response (CR) in injected warts in Group A is seen in 25 (83.3%) patients, partial response (PR) in 3 (10%), and no or inadequate response (NR) in 2 (6.67%) patients. CR is seen in 23 (76.66%) patients of Group B, PR in 4 (13.33%) and no or NR in 3 (10%) patients. CR in distant warts in 22 (73.33%) patients in Group A and 20 (66.66) patients in Group B. Conclusion: Both MMR vaccine and Vitamin D3 are safe, efficacious, and less traumatic to the patients for multiple warts in comparison with destructive modalities.http://www.ijpd.in/article.asp?issn=2319-7250;year=2023;volume=24;issue=2;spage=136;epage=143;aulast=Ahmedmeaslesmumps and rubella vaccinepediatric wartvitamin d3 |
| spellingShingle | Jafir Ahmed Ramesh Kumar Kushwaha Avinash Sharma Morish Agarwal Neha Sharma Suresh Kumar Jain Comparison of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 for the treatment of extragenital warts in pediatric age group (5–18 years) Indian Journal of Paediatric Dermatology measles mumps and rubella vaccine pediatric wart vitamin d3 |
| title | Comparison of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 for the treatment of extragenital warts in pediatric age group (5–18 years) |
| title_full | Comparison of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 for the treatment of extragenital warts in pediatric age group (5–18 years) |
| title_fullStr | Comparison of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 for the treatment of extragenital warts in pediatric age group (5–18 years) |
| title_full_unstemmed | Comparison of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 for the treatment of extragenital warts in pediatric age group (5–18 years) |
| title_short | Comparison of the efficacy of intralesional measles, mumps, and rubella vaccine with intralesional vitamin D3 for the treatment of extragenital warts in pediatric age group (5–18 years) |
| title_sort | comparison of the efficacy of intralesional measles mumps and rubella vaccine with intralesional vitamin d3 for the treatment of extragenital warts in pediatric age group 5 18 years |
| topic | measles mumps and rubella vaccine pediatric wart vitamin d3 |
| url | http://www.ijpd.in/article.asp?issn=2319-7250;year=2023;volume=24;issue=2;spage=136;epage=143;aulast=Ahmed |
| work_keys_str_mv | AT jafirahmed comparisonoftheefficacyofintralesionalmeaslesmumpsandrubellavaccinewithintralesionalvitamind3forthetreatmentofextragenitalwartsinpediatricagegroup518years AT rameshkumarkushwaha comparisonoftheefficacyofintralesionalmeaslesmumpsandrubellavaccinewithintralesionalvitamind3forthetreatmentofextragenitalwartsinpediatricagegroup518years AT avinashsharma comparisonoftheefficacyofintralesionalmeaslesmumpsandrubellavaccinewithintralesionalvitamind3forthetreatmentofextragenitalwartsinpediatricagegroup518years AT morishagarwal comparisonoftheefficacyofintralesionalmeaslesmumpsandrubellavaccinewithintralesionalvitamind3forthetreatmentofextragenitalwartsinpediatricagegroup518years AT nehasharma comparisonoftheefficacyofintralesionalmeaslesmumpsandrubellavaccinewithintralesionalvitamind3forthetreatmentofextragenitalwartsinpediatricagegroup518years AT sureshkumarjain comparisonoftheefficacyofintralesionalmeaslesmumpsandrubellavaccinewithintralesionalvitamind3forthetreatmentofextragenitalwartsinpediatricagegroup518years |