Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM
Gap junction intercellular channels (GJIChs) facilitate direct communication between adjacent cells. Here, authors provide high-resolution information on dynamic structural changes in Cx43 GJICh that are necessary to understand the gating mechanism.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36593-y |
| _version_ | 1797864204664832000 |
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| author | Hyuk-Joon Lee Hyung Jin Cha Hyeongseop Jeong Seu-Na Lee Chang-Won Lee Minsoo Kim Jejoong Yoo Jae-Sung Woo |
| author_facet | Hyuk-Joon Lee Hyung Jin Cha Hyeongseop Jeong Seu-Na Lee Chang-Won Lee Minsoo Kim Jejoong Yoo Jae-Sung Woo |
| author_sort | Hyuk-Joon Lee |
| collection | DOAJ |
| description | Gap junction intercellular channels (GJIChs) facilitate direct communication between adjacent cells. Here, authors provide high-resolution information on dynamic structural changes in Cx43 GJICh that are necessary to understand the gating mechanism. |
| first_indexed | 2024-04-09T22:47:53Z |
| format | Article |
| id | doaj.art-3ade39c189824e13bf2b039251b987e1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:47:53Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3ade39c189824e13bf2b039251b987e12023-03-22T11:42:55ZengNature PortfolioNature Communications2041-17232023-02-0114111810.1038/s41467-023-36593-yConformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EMHyuk-Joon Lee0Hyung Jin Cha1Hyeongseop Jeong2Seu-Na Lee3Chang-Won Lee4Minsoo Kim5Jejoong Yoo6Jae-Sung Woo7Department of Life Sciences, Korea UniversityDepartment of Life Sciences, Korea UniversityDepartment of Life Sciences, Korea UniversityDepartment of Life Sciences, Korea UniversityDepartment of Life Sciences, Korea UniversityDepartment of Physics, Sungkyunkwan UniversityDepartment of Physics, Sungkyunkwan UniversityDepartment of Life Sciences, Korea UniversityGap junction intercellular channels (GJIChs) facilitate direct communication between adjacent cells. Here, authors provide high-resolution information on dynamic structural changes in Cx43 GJICh that are necessary to understand the gating mechanism.https://doi.org/10.1038/s41467-023-36593-y |
| spellingShingle | Hyuk-Joon Lee Hyung Jin Cha Hyeongseop Jeong Seu-Na Lee Chang-Won Lee Minsoo Kim Jejoong Yoo Jae-Sung Woo Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM Nature Communications |
| title | Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM |
| title_full | Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM |
| title_fullStr | Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM |
| title_full_unstemmed | Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM |
| title_short | Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM |
| title_sort | conformational changes in the human cx43 gja1 gap junction channel visualized using cryo em |
| url | https://doi.org/10.1038/s41467-023-36593-y |
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