Brain MR findings in patients treated with particle therapy for skull base tumors
Abstract Nowadays, hadrontherapy is increasingly used for the treatment of various tumors, in particular of those resistant to conventional radiotherapy. Proton and carbon ions are characterized by physical and biological features that allow a high radiation dose to tumors, minimizing irradiation to...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-09-01
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| Series: | Insights into Imaging |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13244-019-0784-9 |
| _version_ | 1818873178562232320 |
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| author | Gisela Viselner Lisa Farina Federica Lucev Elena Turpini Luca Lungarotti Ana Bacila Alberto Iannalfi Emma D’Ippolito Barbara Vischioni Sara Ronchi Enrico Marchioni Francesca Valvo Stefano Bastianello Lorenzo Preda |
| author_facet | Gisela Viselner Lisa Farina Federica Lucev Elena Turpini Luca Lungarotti Ana Bacila Alberto Iannalfi Emma D’Ippolito Barbara Vischioni Sara Ronchi Enrico Marchioni Francesca Valvo Stefano Bastianello Lorenzo Preda |
| author_sort | Gisela Viselner |
| collection | DOAJ |
| description | Abstract Nowadays, hadrontherapy is increasingly used for the treatment of various tumors, in particular of those resistant to conventional radiotherapy. Proton and carbon ions are characterized by physical and biological features that allow a high radiation dose to tumors, minimizing irradiation to adjacent normal tissues. For this reason, radioresistant tumors and tumors located near highly radiosensitive critical organs, such as skull base tumors, represent the best target for this kind of therapy. However, also hadrontherapy can be associated with radiation adverse effects, generally referred as acute, early-delayed and late-delayed. Among late-delayed effects, the most severe form of injury is radiation necrosis. There are various underlying mechanisms involved in the development of radiation necrosis, as well as different clinical presentations requiring specific treatments. In most cases, radiation necrosis presents as a single focal lesion, but it can be multifocal and involve a single or multiple lobes simulating brain metastasis, or it can also involve both cerebral hemispheres. In every case, radiation necrosis results always related to the extension of radiation delivery field. Multiple MRI techniques, including diffusion, perfusion imaging, and spectroscopy, are important tools for the radiologist to formulate the correct diagnosis. The aim of this paper is to illustrate the possible different radiologic patterns of radiation necrosis that can be observed in different MRI techniques in patients treated with hadrontherapy for tumors involving the skull base. The images of exemplary cases of radiation necrosis are also presented. |
| first_indexed | 2024-12-19T12:50:35Z |
| format | Article |
| id | doaj.art-3ade3c0186e64df2930ab37e900aff0d |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-12-19T12:50:35Z |
| publishDate | 2019-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-3ade3c0186e64df2930ab37e900aff0d2022-12-21T20:20:35ZengSpringerOpenInsights into Imaging1869-41012019-09-0110111510.1186/s13244-019-0784-9Brain MR findings in patients treated with particle therapy for skull base tumorsGisela Viselner0Lisa Farina1Federica Lucev2Elena Turpini3Luca Lungarotti4Ana Bacila5Alberto Iannalfi6Emma D’Ippolito7Barbara Vischioni8Sara Ronchi9Enrico Marchioni10Francesca Valvo11Stefano Bastianello12Lorenzo Preda13Diagnostic Imaging Unit, National Center of Oncological Hadrontherapy (CNAO)Neuroradiology Department, IRCCS Mondino FoundationDiagnostic Radiology Residency School, University of PaviaDiagnostic Radiology Residency School, University of PaviaDepartment of Diagnostic and Interventional Radiology and Neuroradiology, Fondazione IRCCS Policlinico San MatteoNeuroradiology Department, IRCCS Mondino FoundationRadiotherapy Unit, National Center of Oncological Hadrontherapy (CNAO)Radiotherapy Unit, National Center of Oncological Hadrontherapy (CNAO)Radiotherapy Unit, National Center of Oncological Hadrontherapy (CNAO)Radiotherapy Unit, National Center of Oncological Hadrontherapy (CNAO)Unit of Neuro-oncology, IRCCS Mondino FoundationRadiotherapy Unit, National Center of Oncological Hadrontherapy (CNAO)Neuroradiology Department, IRCCS Mondino FoundationDiagnostic Imaging Unit, National Center of Oncological Hadrontherapy (CNAO)Abstract Nowadays, hadrontherapy is increasingly used for the treatment of various tumors, in particular of those resistant to conventional radiotherapy. Proton and carbon ions are characterized by physical and biological features that allow a high radiation dose to tumors, minimizing irradiation to adjacent normal tissues. For this reason, radioresistant tumors and tumors located near highly radiosensitive critical organs, such as skull base tumors, represent the best target for this kind of therapy. However, also hadrontherapy can be associated with radiation adverse effects, generally referred as acute, early-delayed and late-delayed. Among late-delayed effects, the most severe form of injury is radiation necrosis. There are various underlying mechanisms involved in the development of radiation necrosis, as well as different clinical presentations requiring specific treatments. In most cases, radiation necrosis presents as a single focal lesion, but it can be multifocal and involve a single or multiple lobes simulating brain metastasis, or it can also involve both cerebral hemispheres. In every case, radiation necrosis results always related to the extension of radiation delivery field. Multiple MRI techniques, including diffusion, perfusion imaging, and spectroscopy, are important tools for the radiologist to formulate the correct diagnosis. The aim of this paper is to illustrate the possible different radiologic patterns of radiation necrosis that can be observed in different MRI techniques in patients treated with hadrontherapy for tumors involving the skull base. The images of exemplary cases of radiation necrosis are also presented.http://link.springer.com/article/10.1186/s13244-019-0784-9HadrontherapyRadiation necrosis brainMultiparametric magnetic resonance imaging |
| spellingShingle | Gisela Viselner Lisa Farina Federica Lucev Elena Turpini Luca Lungarotti Ana Bacila Alberto Iannalfi Emma D’Ippolito Barbara Vischioni Sara Ronchi Enrico Marchioni Francesca Valvo Stefano Bastianello Lorenzo Preda Brain MR findings in patients treated with particle therapy for skull base tumors Insights into Imaging Hadrontherapy Radiation necrosis brain Multiparametric magnetic resonance imaging |
| title | Brain MR findings in patients treated with particle therapy for skull base tumors |
| title_full | Brain MR findings in patients treated with particle therapy for skull base tumors |
| title_fullStr | Brain MR findings in patients treated with particle therapy for skull base tumors |
| title_full_unstemmed | Brain MR findings in patients treated with particle therapy for skull base tumors |
| title_short | Brain MR findings in patients treated with particle therapy for skull base tumors |
| title_sort | brain mr findings in patients treated with particle therapy for skull base tumors |
| topic | Hadrontherapy Radiation necrosis brain Multiparametric magnetic resonance imaging |
| url | http://link.springer.com/article/10.1186/s13244-019-0784-9 |
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