Prevalence of Non Alcoholic Fatty Liver Disease and its Association with Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
Introduction: Non Alcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Mellitus (T2DM) are two common problems affecting global health as these two conditions can influence each other. There is very little information about the possible association between NAFLD and diabetic microvascular c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9823/25931_CE(EK)_F(RK)_PF1(P_SY)_PFA(P_SY).pdf |
| Summary: | Introduction: Non Alcoholic Fatty Liver Disease (NAFLD) and Type
2 Diabetes Mellitus (T2DM) are two common problems affecting
global health as these two conditions can influence each other.
There is very little information about the possible association
between NAFLD and diabetic microvascular complications such
as diabetic nephropathy.
Aim: The aim of this study was to evaluate the prevalence of
NAFLD in patients with T2DM and to investigate the association
between NAFLD and diabetic nephropathy in these patients.
Materials and Methods: This cross-sectional study was
conducted on 255 patients with T2DM, with minimum age
being 30 years. Hepatic ultrasonography using a 3.5 MHz probe
was performed in all subjects. Fatty liver based on standard
criteria was diagnosed with liver brightness, contrast between
the echogenicity of the liver, kidneys and the blood vessels
fading rate. Screening for microalbuminuria was performed by
the preferred method, measurement of the Urine Albumin-ToCreatinine (UACR) ratio in a random spot collection.
Results: In this study, 255 patients with T2DM were enrolled of
which 173 (68%) were females and 82 (32%) were males. Of these
221 subjects (86.66%) had NAFLD. Diabetic nephropathy was
observed among 33% of individuals, microalbuminuria among
32% and macroalbuminuria in 10% of all individuals. Duration
of diabetes, Body Mass Index (BMI), hypertriglyceridemia,
and HbA1c were significantly associated with incidence of
NAFLD. Also, duration of diabetes and HbA1c were significantly
associated with diabetic nephropathy in patients with T2DM.
Conclusion: NAFLD in patients with T2DM is extremely common.
NAFLD is not considered as a risk factor for diabetic nephropathy.
To better understand the pathogenesis of NAFLD and its causal
relationship with complications of diabetes such as diabetic
nephropathy, prospective studies and long term follow up are
needed. |
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| ISSN: | 2249-782X 0973-709X |