Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A

Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A

The UTX/KDM6A histone H3K27 demethylase plays an important role in development and is frequently mutated in cancers such as urothelial cancer. Despite many studies on UTX proteins, variations in mRNA splicing have been overlooked. Using Nanopore sequencing, we present a comprehensive analysis of UTX...

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Bibliographic Details
Main Authors: Omid Fotouhi, Sheikh Nizamuddin, Stephanie Falk, Oliver Schilling, Ruth Knüchel-Clarke, Martin L. Biniossek, H. T. Marc Timmers
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
alternative splicing
histone demethylase
histone methylation
cancer biology
chromatin
proteomics
Online Access:https://www.mdpi.com/2072-6694/15/12/3117

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