Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review
Abstract Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates. As with other vital organ malignancies, proper clinical management invo...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Cellular & Molecular Biology Letters |
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| Online Access: | https://doi.org/10.1186/s11658-022-00307-x |
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| author | M. Kanmalar Siti Fairus Abdul Sani Nur Izzahtul Nabilla B. Kamri Nur Akmarina B. M. Said Amirah Hajirah B. A. Jamil S. Kuppusamy K. S. Mun D. A. Bradley |
| author_facet | M. Kanmalar Siti Fairus Abdul Sani Nur Izzahtul Nabilla B. Kamri Nur Akmarina B. M. Said Amirah Hajirah B. A. Jamil S. Kuppusamy K. S. Mun D. A. Bradley |
| author_sort | M. Kanmalar |
| collection | DOAJ |
| description | Abstract Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates. As with other vital organ malignancies, proper clinical management involves accurate diagnosis and staging. Chemotherapy consisting of a cisplatin-based regimen is the mainstay in the management of muscle-invasive bladder cancers. Control via cisplatin-based chemotherapy is threatened by the development of chemoresistance. Intracellular cholesterol biosynthesis in bladder cancer cells is considered a contributory factor in determining the chemotherapy response. Farnesyl-diphosphate farnesyltransferase 1 (FDFT1), one of the main regulatory components in cholesterol biosynthesis, may play a role in determining sensitivity towards chemotherapy compounds in bladder cancer. FDFT1-associated molecular identification might serve as an alternative or appendage strategy for early prediction of potentially chemoresistant muscle-invasive bladder cancer tissues. This can be accomplished using Raman spectroscopy. Developments in the instrumentation have led to it becoming one of the most convenient forms of analysis, and there is a highly realistic chance that it will become an effective tool in the pathology lab. Chemosensitive bladder cancer tissues tend to have a higher lipid content, more protein genes and more cholesterol metabolites. These are believed to be associated with resistance towards bladder cancer chemotherapy. Herein, Raman peak assignments have been tabulated as an aid to indicating metabolic changes in bladder cancer tissues that are potentially correlated with FDFT1 expression. |
| first_indexed | 2024-12-24T19:06:21Z |
| format | Article |
| id | doaj.art-3ae2ce7582d14fb4b98ad49a3bad6592 |
| institution | Directory Open Access Journal |
| issn | 1425-8153 1689-1392 |
| language | English |
| last_indexed | 2024-12-24T19:06:21Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-3ae2ce7582d14fb4b98ad49a3bad65922022-12-21T16:43:05ZengBMCCellular & Molecular Biology Letters1425-81531689-13922022-01-0127112010.1186/s11658-022-00307-xRaman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a reviewM. Kanmalar0Siti Fairus Abdul Sani1Nur Izzahtul Nabilla B. Kamri2Nur Akmarina B. M. Said3Amirah Hajirah B. A. Jamil4S. Kuppusamy5K. S. Mun6D. A. Bradley7Department of Physics, Faculty of Science, University of MalayaDepartment of Physics, Faculty of Science, University of MalayaDepartment of Physics, Faculty of Science, University of MalayaDepartment of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of MalayaDepartment of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of MalayaDepartment of Surgery, University of MalayaDepartment of Pathology, Faculty of Medicine, University of MalayaCentre for Applied Physics and Radiation Technologies, Sunway UniversityAbstract Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates. As with other vital organ malignancies, proper clinical management involves accurate diagnosis and staging. Chemotherapy consisting of a cisplatin-based regimen is the mainstay in the management of muscle-invasive bladder cancers. Control via cisplatin-based chemotherapy is threatened by the development of chemoresistance. Intracellular cholesterol biosynthesis in bladder cancer cells is considered a contributory factor in determining the chemotherapy response. Farnesyl-diphosphate farnesyltransferase 1 (FDFT1), one of the main regulatory components in cholesterol biosynthesis, may play a role in determining sensitivity towards chemotherapy compounds in bladder cancer. FDFT1-associated molecular identification might serve as an alternative or appendage strategy for early prediction of potentially chemoresistant muscle-invasive bladder cancer tissues. This can be accomplished using Raman spectroscopy. Developments in the instrumentation have led to it becoming one of the most convenient forms of analysis, and there is a highly realistic chance that it will become an effective tool in the pathology lab. Chemosensitive bladder cancer tissues tend to have a higher lipid content, more protein genes and more cholesterol metabolites. These are believed to be associated with resistance towards bladder cancer chemotherapy. Herein, Raman peak assignments have been tabulated as an aid to indicating metabolic changes in bladder cancer tissues that are potentially correlated with FDFT1 expression.https://doi.org/10.1186/s11658-022-00307-xBladder cancerDiagnosticFDFT1Cisplatin chemoresistanceRaman spectroscopy |
| spellingShingle | M. Kanmalar Siti Fairus Abdul Sani Nur Izzahtul Nabilla B. Kamri Nur Akmarina B. M. Said Amirah Hajirah B. A. Jamil S. Kuppusamy K. S. Mun D. A. Bradley Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review Cellular & Molecular Biology Letters Bladder cancer Diagnostic FDFT1 Cisplatin chemoresistance Raman spectroscopy |
| title | Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review |
| title_full | Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review |
| title_fullStr | Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review |
| title_full_unstemmed | Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review |
| title_short | Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review |
| title_sort | raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by fdft1 a review |
| topic | Bladder cancer Diagnostic FDFT1 Cisplatin chemoresistance Raman spectroscopy |
| url | https://doi.org/10.1186/s11658-022-00307-x |
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