Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin
TRPV3 is a non-selective cation channel that is highly expressed in keratinocytes in the skin. Traditionally, keratinocytes-expressed TRPV3 is involved in multiple physiological and pathological functions of the skin, such as itching, heat pain, and hair development. Although the underlying mechanis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/3/513 |
| _version_ | 1797613191600013312 |
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| author | Yaotao Guo Yajuan Song Wei Liu Tong Wang Xianjie Ma Zhou Yu |
| author_facet | Yaotao Guo Yajuan Song Wei Liu Tong Wang Xianjie Ma Zhou Yu |
| author_sort | Yaotao Guo |
| collection | DOAJ |
| description | TRPV3 is a non-selective cation channel that is highly expressed in keratinocytes in the skin. Traditionally, keratinocytes-expressed TRPV3 is involved in multiple physiological and pathological functions of the skin, such as itching, heat pain, and hair development. Although the underlying mechanisms by which TRPV3 functions in vivo remain obscure, recent research studies suggest that several cytokines and EGFR signaling pathways may be involved. However, there have also been other studies with opposite results that question the role of TRPV3 in heat pain. In addition, an increasing number of studies have suggested a novel role of TRPV3 in promoting skin regeneration, indicating that TRPV3 may become a new potential target for regulating skin regeneration. This paper not only reviews the role of keratinocytes-expressed TRPV3 in the physiological and pathological processes of itching, heat pain, hair development, and skin regeneration, but also reviews the relationship between TRPV3 gene mutations and skin diseases such as atopic dermatitis (AD) and Olmsted syndrome (OS). This review will lay a foundation for further developing our understanding of the mechanisms by which TRPV3 is involved in itching, heat pain, and hair development, as well as the treatments for TRPV3-related skin diseases. |
| first_indexed | 2024-03-11T06:52:22Z |
| format | Article |
| id | doaj.art-3ae2fd1b52814ab0b49c371bb5d5ba52 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T06:52:22Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3ae2fd1b52814ab0b49c371bb5d5ba522023-11-17T09:52:20ZengMDPI AGBiomolecules2218-273X2023-03-0113351310.3390/biom13030513Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the SkinYaotao Guo0Yajuan Song1Wei Liu2Tong Wang3Xianjie Ma4Zhou Yu5Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, ChinaTRPV3 is a non-selective cation channel that is highly expressed in keratinocytes in the skin. Traditionally, keratinocytes-expressed TRPV3 is involved in multiple physiological and pathological functions of the skin, such as itching, heat pain, and hair development. Although the underlying mechanisms by which TRPV3 functions in vivo remain obscure, recent research studies suggest that several cytokines and EGFR signaling pathways may be involved. However, there have also been other studies with opposite results that question the role of TRPV3 in heat pain. In addition, an increasing number of studies have suggested a novel role of TRPV3 in promoting skin regeneration, indicating that TRPV3 may become a new potential target for regulating skin regeneration. This paper not only reviews the role of keratinocytes-expressed TRPV3 in the physiological and pathological processes of itching, heat pain, hair development, and skin regeneration, but also reviews the relationship between TRPV3 gene mutations and skin diseases such as atopic dermatitis (AD) and Olmsted syndrome (OS). This review will lay a foundation for further developing our understanding of the mechanisms by which TRPV3 is involved in itching, heat pain, and hair development, as well as the treatments for TRPV3-related skin diseases.https://www.mdpi.com/2218-273X/13/3/513keratinocytesTRPV3itchheat painhair developmentskin regeneration |
| spellingShingle | Yaotao Guo Yajuan Song Wei Liu Tong Wang Xianjie Ma Zhou Yu Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin Biomolecules keratinocytes TRPV3 itch heat pain hair development skin regeneration |
| title | Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin |
| title_full | Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin |
| title_fullStr | Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin |
| title_full_unstemmed | Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin |
| title_short | Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin |
| title_sort | novel insights into the role of keratinocytes expressed trpv3 in the skin |
| topic | keratinocytes TRPV3 itch heat pain hair development skin regeneration |
| url | https://www.mdpi.com/2218-273X/13/3/513 |
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