HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil
Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. Objective: To...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2010-09-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867010700957 |
| _version_ | 1819171222612606976 |
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| author | Edinete Melo da Silva Angelina Xavier Acosta Eduardo José Melo Santos Eduardo Martins Netto Denise Carneiro Lemaire Adriano Silva Oliveira Carolina Matos Barbosa Maria Teresita Bendicho Bernardo Galvão-Castro Carlos Brites |
| author_facet | Edinete Melo da Silva Angelina Xavier Acosta Eduardo José Melo Santos Eduardo Martins Netto Denise Carneiro Lemaire Adriano Silva Oliveira Carolina Matos Barbosa Maria Teresita Bendicho Bernardo Galvão-Castro Carlos Brites |
| author_sort | Edinete Melo da Silva |
| collection | DOAJ |
| description | Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. Objective: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. Methods: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specific oligonucleotide probes following amplification of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisheŕs exact and ANOVA tests for categorical and continuous variables, respectively. Results: We detected a significant association (χ2 = 4.856; p = 0.018) between the presence of HLA-Bw4 and low levels of viremia. Eighteen out of the 147 HIV-infected individuals presented viremia ≤ 1,800 copies/mL and 129 presented viremia > 2,000 copies/mL. Ninety and four percent (17/18) of all individuals with viremia ≤ 1,800 copies/ mL carried HLA-Bw4, compared to 67.4% (87/129) of individuals with viremia > 2,000 copies/mL. Additionally, we found a significantly higher frequency of B*57 (OR = 13.94; 95% CI = 4.19-46.38; p < 0.0001) and Cw*18 (OR = 16.15; 95% CI = 3.46-75.43; p ≤ 0.0001) alleles, favoring the group with lower viremia levels, in comparison with those with higher viral load. Conclusion: HLA-Bw4-B*57 and Cw*18 alleles are associated with lower level of viral load in HIV-infected Brazilian patients. These findings may help us in understanding the determinants of HIV evolution in Brazilian patients, as well as in providing important information on immune response correlates of protection for such population. Keywords: HIV, AIDS, MHC, HLA, polymorphism |
| first_indexed | 2024-12-22T19:47:52Z |
| format | Article |
| id | doaj.art-3ae347b014484bbf9666aeae9b17b9e3 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-22T19:47:52Z |
| publishDate | 2010-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-3ae347b014484bbf9666aeae9b17b9e32022-12-21T18:14:38ZengElsevierBrazilian Journal of Infectious Diseases1413-86702010-09-01145468475HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, BrazilEdinete Melo da Silva0Angelina Xavier Acosta1Eduardo José Melo Santos2Eduardo Martins Netto3Denise Carneiro Lemaire4Adriano Silva Oliveira5Carolina Matos Barbosa6Maria Teresita Bendicho7Bernardo Galvão-Castro8Carlos Brites9Infectology Research Laboratory of Hospital Universitário Professor Edgard Santos – HUPES – UFBA, Brazil; Advanced Laboratory of Public Health - LASP/ CPQGM/FIOCRUZ, Brazil; Correspondence to: Laboratório de Pesquisa em Infectologia, Hospital Universitário Professor Edgard Santos Rua Augusto Viana, S/N-Canela, 6° andar, Salvador – Bahia – Brazil CEP: 40110-060, Phone: +55-71-32838126; Fax: +55-71-32472756.Advanced Laboratory of Public Health - LASP/ CPQGM/FIOCRUZ, Brazil; Department of Pediatrics, School of Medicine, UFBA, BrazillDepartment of Pediatrics, School of Medicine, UFBA, BrazillInfectology Research Laboratory of Hospital Universitário Professor Edgard Santos – HUPES – UFBA, BrazilLaboratory of Immunology of Instituto das Ciências e Saúde - ICS/UFBA, Salvador – BA, BrazilInfectology Research Laboratory of Hospital Universitário Professor Edgard Santos – HUPES – UFBA, BrazilLaboratory of Humam and Medical Genetics, Biological Sciences Center, UFPA, Belém – PA, BrazilLaboratory of Immunology of Instituto das Ciências e Saúde - ICS/UFBA, Salvador – BA, BrazilAdvanced Laboratory of Public Health - LASP/ CPQGM/FIOCRUZ, BrazilInfectology Research Laboratory of Hospital Universitário Professor Edgard Santos – HUPES – UFBA, BrazilHost genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. Objective: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. Methods: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specific oligonucleotide probes following amplification of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisheŕs exact and ANOVA tests for categorical and continuous variables, respectively. Results: We detected a significant association (χ2 = 4.856; p = 0.018) between the presence of HLA-Bw4 and low levels of viremia. Eighteen out of the 147 HIV-infected individuals presented viremia ≤ 1,800 copies/mL and 129 presented viremia > 2,000 copies/mL. Ninety and four percent (17/18) of all individuals with viremia ≤ 1,800 copies/ mL carried HLA-Bw4, compared to 67.4% (87/129) of individuals with viremia > 2,000 copies/mL. Additionally, we found a significantly higher frequency of B*57 (OR = 13.94; 95% CI = 4.19-46.38; p < 0.0001) and Cw*18 (OR = 16.15; 95% CI = 3.46-75.43; p ≤ 0.0001) alleles, favoring the group with lower viremia levels, in comparison with those with higher viral load. Conclusion: HLA-Bw4-B*57 and Cw*18 alleles are associated with lower level of viral load in HIV-infected Brazilian patients. These findings may help us in understanding the determinants of HIV evolution in Brazilian patients, as well as in providing important information on immune response correlates of protection for such population. Keywords: HIV, AIDS, MHC, HLA, polymorphismhttp://www.sciencedirect.com/science/article/pii/S1413867010700957 |
| spellingShingle | Edinete Melo da Silva Angelina Xavier Acosta Eduardo José Melo Santos Eduardo Martins Netto Denise Carneiro Lemaire Adriano Silva Oliveira Carolina Matos Barbosa Maria Teresita Bendicho Bernardo Galvão-Castro Carlos Brites HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil Brazilian Journal of Infectious Diseases |
| title | HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_full | HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_fullStr | HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_full_unstemmed | HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_short | HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_sort | hla bw4 b 57 and cw 18 alleles are associated with plasma viral load modulation in hiv 1 infected individuals in salvador brazil |
| url | http://www.sciencedirect.com/science/article/pii/S1413867010700957 |
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