Ritonavir associated maculopathy– multimodal imaging and electrophysiology findings
Purpose: To report the case 47-year-old patient presenting with severe maculopathy associated with long-term ritonavir treatment. Methods: Observational case report of one patient and literature review. Results: A 47 year-old Caucasian man presented with progressive bilateral vision loss for the pas...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993619300957 |
| _version_ | 1818404584226291712 |
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| author | Roxane Bunod Alexandra Miere Olivia Zambrowski Pierre-Marie Girard Laure Surgers Eric H. Souied |
| author_facet | Roxane Bunod Alexandra Miere Olivia Zambrowski Pierre-Marie Girard Laure Surgers Eric H. Souied |
| author_sort | Roxane Bunod |
| collection | DOAJ |
| description | Purpose: To report the case 47-year-old patient presenting with severe maculopathy associated with long-term ritonavir treatment. Methods: Observational case report of one patient and literature review. Results: A 47 year-old Caucasian man presented with progressive bilateral vision loss for the past 5 years. His medical history included Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) coinfection since 1992. He was treated by highly active antiretroviral therapy for 24 years including 4 years of didanosine treatment and 18 years of ritonavir treatment. Bilateral extensive macular atrophy with foveal sparing on the left eye and absence of midperipheral/peripheral retina involvement was confirmed on multimodal imaging and functional testing including swept-source OCT angiography and electroretinography. Conclusion: Ritonavir associated maculopathy is a scarcely described medication-associated retinopathy. In this case, an extensive macular atrophy (with complete loss of photoreceptor, RPE and choriocapillaris layers) and subsequent cone-rod dysfunction appeared after 18 years of ritonavir exposure. |
| first_indexed | 2024-12-14T08:42:28Z |
| format | Article |
| id | doaj.art-3ae35800fb8b409dacc6fd6f2728e384 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-14T08:42:28Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-3ae35800fb8b409dacc6fd6f2728e3842022-12-21T23:09:15ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362020-09-0119100783Ritonavir associated maculopathy– multimodal imaging and electrophysiology findingsRoxane Bunod0Alexandra Miere1Olivia Zambrowski2Pierre-Marie Girard3Laure Surgers4Eric H. Souied5Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, 40 Avenue de Verdun, 94000, Creteil, FranceDepartment of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, 40 Avenue de Verdun, 94000, Creteil, FranceDepartment of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, 40 Avenue de Verdun, 94000, Creteil, FranceDepartment of Infectious and Tropical Diseases, Hôpital Saint Antoine, AP-HP and UMRS, 1136, Sorbonne Université, F75013, Paris, FranceDepartment of Infectious and Tropical Diseases, Hôpital Saint Antoine, AP-HP and UMRS, 1136, Sorbonne Université, F75013, Paris, FranceDepartment of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, 40 Avenue de Verdun, 94000, Creteil, France; Corresponding author. Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 40 Avenue de Verdun, 94000, Creteil, France.Purpose: To report the case 47-year-old patient presenting with severe maculopathy associated with long-term ritonavir treatment. Methods: Observational case report of one patient and literature review. Results: A 47 year-old Caucasian man presented with progressive bilateral vision loss for the past 5 years. His medical history included Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) coinfection since 1992. He was treated by highly active antiretroviral therapy for 24 years including 4 years of didanosine treatment and 18 years of ritonavir treatment. Bilateral extensive macular atrophy with foveal sparing on the left eye and absence of midperipheral/peripheral retina involvement was confirmed on multimodal imaging and functional testing including swept-source OCT angiography and electroretinography. Conclusion: Ritonavir associated maculopathy is a scarcely described medication-associated retinopathy. In this case, an extensive macular atrophy (with complete loss of photoreceptor, RPE and choriocapillaris layers) and subsequent cone-rod dysfunction appeared after 18 years of ritonavir exposure.http://www.sciencedirect.com/science/article/pii/S2451993619300957MaculopathyHIVAntiretroviral medicationRitonavirMultimodal imaging |
| spellingShingle | Roxane Bunod Alexandra Miere Olivia Zambrowski Pierre-Marie Girard Laure Surgers Eric H. Souied Ritonavir associated maculopathy– multimodal imaging and electrophysiology findings American Journal of Ophthalmology Case Reports Maculopathy HIV Antiretroviral medication Ritonavir Multimodal imaging |
| title | Ritonavir associated maculopathy– multimodal imaging and electrophysiology findings |
| title_full | Ritonavir associated maculopathy– multimodal imaging and electrophysiology findings |
| title_fullStr | Ritonavir associated maculopathy– multimodal imaging and electrophysiology findings |
| title_full_unstemmed | Ritonavir associated maculopathy– multimodal imaging and electrophysiology findings |
| title_short | Ritonavir associated maculopathy– multimodal imaging and electrophysiology findings |
| title_sort | ritonavir associated maculopathy multimodal imaging and electrophysiology findings |
| topic | Maculopathy HIV Antiretroviral medication Ritonavir Multimodal imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2451993619300957 |
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