An integration-free iPSC line ZZUNEUi029-A derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in LDLR gene
Familial hypercholesterolemia is a hereditary disorder that causes severely elevated low-density lipoprotein levels, which can lead to an increased risk for premature cardiovascular disease. Mutations in the LDLR gene are the most common cause of familial hypercholesterolemia. In this study, we repo...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187350612300168X |
| _version_ | 1797692039776698368 |
|---|---|
| author | Kui Zhu Jiangtao Zhao Fen Qin Xiaowei Chen Haonan Xu Xiaowei Li Hailong Tao |
| author_facet | Kui Zhu Jiangtao Zhao Fen Qin Xiaowei Chen Haonan Xu Xiaowei Li Hailong Tao |
| author_sort | Kui Zhu |
| collection | DOAJ |
| description | Familial hypercholesterolemia is a hereditary disorder that causes severely elevated low-density lipoprotein levels, which can lead to an increased risk for premature cardiovascular disease. Mutations in the LDLR gene are the most common cause of familial hypercholesterolemia. In this study, we report the generation of ZZUNEUi029-A, a human induced pluripotent stem cell line (hiPSC) from a male patient with c. 622 G → A in LDLR gene using non-integrative Sendai viral reprogramming technology. This cell line expressed pluripotency markers, had a normal male karyotype (46XY) and maintained the ability to differentiate into the three germ layers in vitro. |
| first_indexed | 2024-03-12T02:21:56Z |
| format | Article |
| id | doaj.art-3ae3f7e879d443339a4b5d1b55e72727 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-12T02:21:56Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-3ae3f7e879d443339a4b5d1b55e727272023-09-06T04:50:56ZengElsevierStem Cell Research1873-50612023-09-0171103182An integration-free iPSC line ZZUNEUi029-A derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in LDLR geneKui Zhu0Jiangtao Zhao1Fen Qin2Xiaowei Chen3Haonan Xu4Xiaowei Li5Hailong Tao6Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of Hereditary Cardiovascular Diseases, Zhengzhou 450052, China; Corresponding authors.Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Corresponding authors.Familial hypercholesterolemia is a hereditary disorder that causes severely elevated low-density lipoprotein levels, which can lead to an increased risk for premature cardiovascular disease. Mutations in the LDLR gene are the most common cause of familial hypercholesterolemia. In this study, we report the generation of ZZUNEUi029-A, a human induced pluripotent stem cell line (hiPSC) from a male patient with c. 622 G → A in LDLR gene using non-integrative Sendai viral reprogramming technology. This cell line expressed pluripotency markers, had a normal male karyotype (46XY) and maintained the ability to differentiate into the three germ layers in vitro.http://www.sciencedirect.com/science/article/pii/S187350612300168X |
| spellingShingle | Kui Zhu Jiangtao Zhao Fen Qin Xiaowei Chen Haonan Xu Xiaowei Li Hailong Tao An integration-free iPSC line ZZUNEUi029-A derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in LDLR gene Stem Cell Research |
| title | An integration-free iPSC line ZZUNEUi029-A derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in LDLR gene |
| title_full | An integration-free iPSC line ZZUNEUi029-A derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in LDLR gene |
| title_fullStr | An integration-free iPSC line ZZUNEUi029-A derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in LDLR gene |
| title_full_unstemmed | An integration-free iPSC line ZZUNEUi029-A derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in LDLR gene |
| title_short | An integration-free iPSC line ZZUNEUi029-A derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in LDLR gene |
| title_sort | integration free ipsc line zzuneui029 a derived from peripheral blood mononuclear cells of a patient with familial hypercholesterolemia carrying a mutation in ldlr gene |
| url | http://www.sciencedirect.com/science/article/pii/S187350612300168X |
| work_keys_str_mv | AT kuizhu anintegrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT jiangtaozhao anintegrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT fenqin anintegrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT xiaoweichen anintegrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT haonanxu anintegrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT xiaoweili anintegrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT hailongtao anintegrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT kuizhu integrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT jiangtaozhao integrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT fenqin integrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT xiaoweichen integrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT haonanxu integrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT xiaoweili integrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene AT hailongtao integrationfreeipsclinezzuneui029aderivedfromperipheralbloodmononuclearcellsofapatientwithfamilialhypercholesterolemiacarryingamutationinldlrgene |