Controlling the thickness of the atherosclerotic plaque by statin medication.
Atherosclerosis, a chronic inflammatory disorder of the arterial wall, is a complex process whose dynamics are affected by multiple factors. The disease control consists of restraining it by administering statins. Slowing down or halting the plaque growth depends on the patient age at which the stat...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0239953 |
| _version_ | 1818361938528174080 |
|---|---|
| author | Dorota Formanowicz Jacek B Krawczyk |
| author_facet | Dorota Formanowicz Jacek B Krawczyk |
| author_sort | Dorota Formanowicz |
| collection | DOAJ |
| description | Atherosclerosis, a chronic inflammatory disorder of the arterial wall, is a complex process whose dynamics are affected by multiple factors. The disease control consists of restraining it by administering statins. Slowing down or halting the plaque growth depends on the patient age at which the statin treatment begins and on the thickness of the intima-media (IMT) at that time. In this paper, we propose a mathematical model to estimate the sets of atherosclerosis states, from which the use of statins can restrain the disease. Our model is control-theoretic, and the estimated sets are the viability kernels, in the parlance of viability theory. To our best knowledge, this way of modelling the atherosclerosis progression is original. We compute two viability kernels, each for a different statin-treatment dose. Each kernel is composed of the vector [age, IMT] from which the disease can be restrained. By extension, the disease can't be restrained from the kernel complements, this being mainly because of the disease and patient-age advancement. The kernels visualise tradeoffs between early and late treatments, which helps the clinician to decide when to start the statin treatment and which statin dose may be sufficient. |
| first_indexed | 2024-12-13T21:24:38Z |
| format | Article |
| id | doaj.art-3ae4e586671945d2977c38d1c6f1252d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T21:24:38Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3ae4e586671945d2977c38d1c6f1252d2022-12-21T23:30:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011510e023995310.1371/journal.pone.0239953Controlling the thickness of the atherosclerotic plaque by statin medication.Dorota FormanowiczJacek B KrawczykAtherosclerosis, a chronic inflammatory disorder of the arterial wall, is a complex process whose dynamics are affected by multiple factors. The disease control consists of restraining it by administering statins. Slowing down or halting the plaque growth depends on the patient age at which the statin treatment begins and on the thickness of the intima-media (IMT) at that time. In this paper, we propose a mathematical model to estimate the sets of atherosclerosis states, from which the use of statins can restrain the disease. Our model is control-theoretic, and the estimated sets are the viability kernels, in the parlance of viability theory. To our best knowledge, this way of modelling the atherosclerosis progression is original. We compute two viability kernels, each for a different statin-treatment dose. Each kernel is composed of the vector [age, IMT] from which the disease can be restrained. By extension, the disease can't be restrained from the kernel complements, this being mainly because of the disease and patient-age advancement. The kernels visualise tradeoffs between early and late treatments, which helps the clinician to decide when to start the statin treatment and which statin dose may be sufficient.https://doi.org/10.1371/journal.pone.0239953 |
| spellingShingle | Dorota Formanowicz Jacek B Krawczyk Controlling the thickness of the atherosclerotic plaque by statin medication. PLoS ONE |
| title | Controlling the thickness of the atherosclerotic plaque by statin medication. |
| title_full | Controlling the thickness of the atherosclerotic plaque by statin medication. |
| title_fullStr | Controlling the thickness of the atherosclerotic plaque by statin medication. |
| title_full_unstemmed | Controlling the thickness of the atherosclerotic plaque by statin medication. |
| title_short | Controlling the thickness of the atherosclerotic plaque by statin medication. |
| title_sort | controlling the thickness of the atherosclerotic plaque by statin medication |
| url | https://doi.org/10.1371/journal.pone.0239953 |
| work_keys_str_mv | AT dorotaformanowicz controllingthethicknessoftheatheroscleroticplaquebystatinmedication AT jacekbkrawczyk controllingthethicknessoftheatheroscleroticplaquebystatinmedication |