Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration
The epicardium supports heart regeneration, though precisely how is unclear. Here the authors define an activated epicardial progenitor population as the source of essential cell types and paracrine factors for successful heart regeneration in zebrafish.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35433-9 |
| _version_ | 1798005127892697088 |
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| author | Yu Xia Sierra Duca Björn Perder Friederike Dündar Paul Zumbo Miaoyan Qiu Jun Yao Yingxi Cao Michael R. M. Harrison Lior Zangi Doron Betel Jingli Cao |
| author_facet | Yu Xia Sierra Duca Björn Perder Friederike Dündar Paul Zumbo Miaoyan Qiu Jun Yao Yingxi Cao Michael R. M. Harrison Lior Zangi Doron Betel Jingli Cao |
| author_sort | Yu Xia |
| collection | DOAJ |
| description | The epicardium supports heart regeneration, though precisely how is unclear. Here the authors define an activated epicardial progenitor population as the source of essential cell types and paracrine factors for successful heart regeneration in zebrafish. |
| first_indexed | 2024-04-11T12:35:19Z |
| format | Article |
| id | doaj.art-3ae641996c0f41c8ae565e948ca8a1a7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T12:35:19Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3ae641996c0f41c8ae565e948ca8a1a72022-12-22T04:23:39ZengNature PortfolioNature Communications2041-17232022-12-0113111810.1038/s41467-022-35433-9Activation of a transient progenitor state in the epicardium is required for zebrafish heart regenerationYu Xia0Sierra Duca1Björn Perder2Friederike Dündar3Paul Zumbo4Miaoyan Qiu5Jun Yao6Yingxi Cao7Michael R. M. Harrison8Lior Zangi9Doron Betel10Jingli Cao11Cardiovascular Research Institute, Weill Cornell Medical CollegeCardiovascular Research Institute, Weill Cornell Medical CollegeCardiovascular Research Institute, Weill Cornell Medical CollegeDepartment of Physiology and Biophysics, Weill Cornell Medical CollegeDepartment of Physiology and Biophysics, Weill Cornell Medical CollegeCardiovascular Research Institute, Weill Cornell Medical CollegeCardiovascular Research Institute, Weill Cornell Medical CollegeCardiovascular Research Institute, Weill Cornell Medical CollegeCardiovascular Research Institute, Weill Cornell Medical CollegeCardiovascular Research Institute, Icahn School of Medicine at Mount SinaiApplied Bioinformatics Core, Weill Cornell Medical CollegeCardiovascular Research Institute, Weill Cornell Medical CollegeThe epicardium supports heart regeneration, though precisely how is unclear. Here the authors define an activated epicardial progenitor population as the source of essential cell types and paracrine factors for successful heart regeneration in zebrafish.https://doi.org/10.1038/s41467-022-35433-9 |
| spellingShingle | Yu Xia Sierra Duca Björn Perder Friederike Dündar Paul Zumbo Miaoyan Qiu Jun Yao Yingxi Cao Michael R. M. Harrison Lior Zangi Doron Betel Jingli Cao Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration Nature Communications |
| title | Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration |
| title_full | Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration |
| title_fullStr | Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration |
| title_full_unstemmed | Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration |
| title_short | Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration |
| title_sort | activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration |
| url | https://doi.org/10.1038/s41467-022-35433-9 |
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