Laxative effect of mulberry ferment on two models of constipated mice
This study was to probe the effects of mulberry ferment on constipation (induced by diphenoxylate or loperamide) in mice. Herein, several bioactive substances and antioxidant activities of mulberry ferment were measured, and their effects on defecation, histological structure of ileum and intestinal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462200041X |
| _version_ | 1828127911467548672 |
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| author | Yanghang He Gang Liu Chen Xia Jian Chen Jiayuan Zhao Xueli Li Junlin Deng Xueli Wang Zhuoya Xiang Peng Zeng |
| author_facet | Yanghang He Gang Liu Chen Xia Jian Chen Jiayuan Zhao Xueli Li Junlin Deng Xueli Wang Zhuoya Xiang Peng Zeng |
| author_sort | Yanghang He |
| collection | DOAJ |
| description | This study was to probe the effects of mulberry ferment on constipation (induced by diphenoxylate or loperamide) in mice. Herein, several bioactive substances and antioxidant activities of mulberry ferment were measured, and their effects on defecation, histological structure of ileum and intestinal microflora were investigated. During fermentation, total polyphenols, and flavonoids were increased while the antioxidant activities increased by a large extent. In animal experiments, diphenoxylate caused more serious injuries than loperamide did, and diphenoxylate kept the more unfavorable gut microbiological environment compared with loperamide. Administration of mulberry ferment can increase the fecal moisture content, shorten the first black fecal defecation time, and accelerate the gastro-intestinal transit. Besides, mulberry ferment alleviated ileal tissue organ injuries caused by constipation, suppressed the level of Oscillibacter and Desulfovibrio and increased the Bacteroidales and Bacteroidales_S24-7. In summary, mulberry ferment could be considered as a promising functional food because of their good alleviation on constipation. |
| first_indexed | 2024-04-11T15:56:39Z |
| format | Article |
| id | doaj.art-3ae7ad8c4e734fbab0893b8ba17675f6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T15:56:39Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-3ae7ad8c4e734fbab0893b8ba17675f62022-12-22T04:15:08ZengElsevierJournal of Functional Foods1756-46462022-03-0190104971Laxative effect of mulberry ferment on two models of constipated miceYanghang He0Gang Liu1Chen Xia2Jian Chen3Jiayuan Zhao4Xueli Li5Junlin Deng6Xueli Wang7Zhuoya Xiang8Peng Zeng9College of Life Science, Sichuan Normal University, Longquanyi District, Sichuan 610100, PR ChinaCollege of Life Science, Sichuan Normal University, Longquanyi District, Sichuan 610100, PR ChinaInstitute of Agro-Products Processing Science and Technology, Sichuan Academy of Agricultural Sciences, Chengdu 610066, ChinaInstitute of Agro-Products Processing Science and Technology, Sichuan Academy of Agricultural Sciences, Chengdu 610066, ChinaCollege of Life Science, Sichuan Normal University, Longquanyi District, Sichuan 610100, PR ChinaSchool of Laboratory Medicine, Chengdu Medical College, No. 783 Xin Du Avenue, Chengdu 610101, China; Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-origin Food, Chengdu Medical College, Chengdu 610101, China; Corresponding author at: School of Laboratory Medicine, Chengdu Medical College, No. 783 Xin Du Avenue, Chengdu 610101, China.Institute of Agro-Products Processing Science and Technology, Sichuan Academy of Agricultural Sciences, Chengdu 610066, ChinaCollege of Life Science, Sichuan Normal University, Longquanyi District, Sichuan 610100, PR ChinaInstitute of Agro-Products Processing Science and Technology, Sichuan Academy of Agricultural Sciences, Chengdu 610066, ChinaYibin university, Solid-state Fermentation Resource Utilization Key Laboratory of Sichuan Province, Sichuan 644000, ChinaThis study was to probe the effects of mulberry ferment on constipation (induced by diphenoxylate or loperamide) in mice. Herein, several bioactive substances and antioxidant activities of mulberry ferment were measured, and their effects on defecation, histological structure of ileum and intestinal microflora were investigated. During fermentation, total polyphenols, and flavonoids were increased while the antioxidant activities increased by a large extent. In animal experiments, diphenoxylate caused more serious injuries than loperamide did, and diphenoxylate kept the more unfavorable gut microbiological environment compared with loperamide. Administration of mulberry ferment can increase the fecal moisture content, shorten the first black fecal defecation time, and accelerate the gastro-intestinal transit. Besides, mulberry ferment alleviated ileal tissue organ injuries caused by constipation, suppressed the level of Oscillibacter and Desulfovibrio and increased the Bacteroidales and Bacteroidales_S24-7. In summary, mulberry ferment could be considered as a promising functional food because of their good alleviation on constipation.http://www.sciencedirect.com/science/article/pii/S175646462200041XConstipationMulberry fermentDiphenoxylateLoperamideGut microbiota |
| spellingShingle | Yanghang He Gang Liu Chen Xia Jian Chen Jiayuan Zhao Xueli Li Junlin Deng Xueli Wang Zhuoya Xiang Peng Zeng Laxative effect of mulberry ferment on two models of constipated mice Journal of Functional Foods Constipation Mulberry ferment Diphenoxylate Loperamide Gut microbiota |
| title | Laxative effect of mulberry ferment on two models of constipated mice |
| title_full | Laxative effect of mulberry ferment on two models of constipated mice |
| title_fullStr | Laxative effect of mulberry ferment on two models of constipated mice |
| title_full_unstemmed | Laxative effect of mulberry ferment on two models of constipated mice |
| title_short | Laxative effect of mulberry ferment on two models of constipated mice |
| title_sort | laxative effect of mulberry ferment on two models of constipated mice |
| topic | Constipation Mulberry ferment Diphenoxylate Loperamide Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S175646462200041X |
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