The Transcriptional Regulation of Germinal Center Formation
Germinal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell dependent antigens. During the GC reaction, B cells undergo critical differentiation steps, which ultimately lead to the generation of antibodies with altered effector fu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02026/full |
| _version_ | 1818531025218699264 |
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| author | Shuang Song Shuang Song Patrick D. Matthias Patrick D. Matthias |
| author_facet | Shuang Song Shuang Song Patrick D. Matthias Patrick D. Matthias |
| author_sort | Shuang Song |
| collection | DOAJ |
| description | Germinal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell dependent antigens. During the GC reaction, B cells undergo critical differentiation steps, which ultimately lead to the generation of antibodies with altered effector function and higher affinity for the selected antigen. Remarkably, many of the B cell tumors have their origin in the GCs; thus, understanding how the formation of these structures is regulated or deregulated is of high medical importance. This review gives an overview of the transcription factors that have been linked to the generation of GCs, and of their roles in the process. |
| first_indexed | 2024-12-11T17:27:07Z |
| format | Article |
| id | doaj.art-3aeb9fecfeb241eab5814d2bbc5005b3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T17:27:07Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3aeb9fecfeb241eab5814d2bbc5005b32022-12-22T00:56:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02026411463The Transcriptional Regulation of Germinal Center FormationShuang Song0Shuang Song1Patrick D. Matthias2Patrick D. Matthias3Friedrich Miescher Institute for Biomedical Research, Basel, SwitzerlandFaculty of Sciences, University of Basel, Basel, SwitzerlandFriedrich Miescher Institute for Biomedical Research, Basel, SwitzerlandFaculty of Sciences, University of Basel, Basel, SwitzerlandGerminal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell dependent antigens. During the GC reaction, B cells undergo critical differentiation steps, which ultimately lead to the generation of antibodies with altered effector function and higher affinity for the selected antigen. Remarkably, many of the B cell tumors have their origin in the GCs; thus, understanding how the formation of these structures is regulated or deregulated is of high medical importance. This review gives an overview of the transcription factors that have been linked to the generation of GCs, and of their roles in the process.https://www.frontiersin.org/article/10.3389/fimmu.2018.02026/fullhematopoiesistranscription factorsB cell developmentgerminal center (GCs)transcriptional regulationgerminal center development |
| spellingShingle | Shuang Song Shuang Song Patrick D. Matthias Patrick D. Matthias The Transcriptional Regulation of Germinal Center Formation Frontiers in Immunology hematopoiesis transcription factors B cell development germinal center (GCs) transcriptional regulation germinal center development |
| title | The Transcriptional Regulation of Germinal Center Formation |
| title_full | The Transcriptional Regulation of Germinal Center Formation |
| title_fullStr | The Transcriptional Regulation of Germinal Center Formation |
| title_full_unstemmed | The Transcriptional Regulation of Germinal Center Formation |
| title_short | The Transcriptional Regulation of Germinal Center Formation |
| title_sort | transcriptional regulation of germinal center formation |
| topic | hematopoiesis transcription factors B cell development germinal center (GCs) transcriptional regulation germinal center development |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02026/full |
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