Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease
Background Levodopa is the most used and effective medication for motor symptoms of Parkinson disease (PD), its long-term use is associated with the appearance of levodopa-induced dyskinesia (LID). Uric acid (UA) is believed to play an important neuroprotective role in PD. Objective To in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2023-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761294 |
| _version_ | 1797870650295058432 |
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| author | Nayron Medeiros Soares Gabriela Magalhães Pereira Ana Carolina Leonardi Dutra Nathalie Ribeiro Artigas Júlia Schneider Krimberg Bruno Elkfury Monticelli Artur Francisco Schumacher-Schuh Rosa Maria Martins de Almeida Carlos Roberto de Mello Rieder |
| author_facet | Nayron Medeiros Soares Gabriela Magalhães Pereira Ana Carolina Leonardi Dutra Nathalie Ribeiro Artigas Júlia Schneider Krimberg Bruno Elkfury Monticelli Artur Francisco Schumacher-Schuh Rosa Maria Martins de Almeida Carlos Roberto de Mello Rieder |
| author_sort | Nayron Medeiros Soares |
| collection | DOAJ |
| description | Background Levodopa is the most used and effective medication for motor symptoms of Parkinson disease (PD), its long-term use is associated with the appearance of levodopa-induced dyskinesia (LID). Uric acid (UA) is believed to play an important neuroprotective role in PD.
Objective To investigate if serum UA levels are related with the presence of LIDs in PD patients. Also, we investigated the associations among UA levels and clinical features of PD.
Methods We enrolled 81 PD patients (dyskinesia = 48; no dyskinesia = 33) in the present study. A blood sample was collected to evaluate serum UA levels, clinical evaluation included the following instruments: Montreal Cognitive Assessment (MoCA), Beck Depression Inventory II (BDI-II), MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Hoehn and Yahr (HY), and the sub-item 4.1 of MDS-UPDRS IV (score ≥ 1). Additional relevant clinical information was obtained by a clinical questionnaire.
Results Serum UA levels were lower in the dyskinesia group when compared with the no dyskinesia group. The same result was found in the UA levels of both men and women. The multivariate analysis showed lower uric acid levels were significantly associated with having dyskinesia (odds ratio [OR] = 0.424; 95% confidence interval [CI]: 0.221–0.746; p = 0.005). Additional analysis verified that serum UA levels are inversely correlated with depressive symptoms, disease duration, MDS-UPDRS IV and time spent with dyskinesia. A positive correlation was found with age at onset of PD symptoms.
Conclusions The present study provides a possible role of serum UA levels in LID present in PD patients. |
| first_indexed | 2024-04-10T00:31:51Z |
| format | Article |
| id | doaj.art-3aec91e1f7364e4da66f74fa72bd0873 |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-04-10T00:31:51Z |
| publishDate | 2023-01-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-3aec91e1f7364e4da66f74fa72bd08732023-03-14T23:44:04ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272023-01-01810104004610.1055/s-0043-1761294Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's diseaseNayron Medeiros Soares0Gabriela Magalhães Pereira1Ana Carolina Leonardi Dutra2Nathalie Ribeiro Artigas3Júlia Schneider Krimberg4Bruno Elkfury Monticelli5Artur Francisco Schumacher-Schuh6Rosa Maria Martins de Almeida7Carlos Roberto de Mello Rieder8Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre RS, Brazil.Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre RS, Brazil.Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre RS, Brazil.Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre RS, Brazil.Hospital de Clínicas de Porto Alegre, Serviço de Neurologia, Porto Alegre RS, Brazil.Hospital de Clínicas de Porto Alegre, Serviço de Neurologia, Porto Alegre RS, Brazil.Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre RS, Brazil.Universidade Federal do Rio Grande do Sul, Instituto de Psicologia, Porto Alegre RS, Brazil.Irmandade Santa Casa de Misericórdia de Porto Alegre, Serviço de Neurologia, Porto Alegre RS, Brazil.Background Levodopa is the most used and effective medication for motor symptoms of Parkinson disease (PD), its long-term use is associated with the appearance of levodopa-induced dyskinesia (LID). Uric acid (UA) is believed to play an important neuroprotective role in PD. Objective To investigate if serum UA levels are related with the presence of LIDs in PD patients. Also, we investigated the associations among UA levels and clinical features of PD. Methods We enrolled 81 PD patients (dyskinesia = 48; no dyskinesia = 33) in the present study. A blood sample was collected to evaluate serum UA levels, clinical evaluation included the following instruments: Montreal Cognitive Assessment (MoCA), Beck Depression Inventory II (BDI-II), MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Hoehn and Yahr (HY), and the sub-item 4.1 of MDS-UPDRS IV (score ≥ 1). Additional relevant clinical information was obtained by a clinical questionnaire. Results Serum UA levels were lower in the dyskinesia group when compared with the no dyskinesia group. The same result was found in the UA levels of both men and women. The multivariate analysis showed lower uric acid levels were significantly associated with having dyskinesia (odds ratio [OR] = 0.424; 95% confidence interval [CI]: 0.221–0.746; p = 0.005). Additional analysis verified that serum UA levels are inversely correlated with depressive symptoms, disease duration, MDS-UPDRS IV and time spent with dyskinesia. A positive correlation was found with age at onset of PD symptoms. Conclusions The present study provides a possible role of serum UA levels in LID present in PD patients.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761294parkinson diseaseuric aciddyskinesiaslevodopa |
| spellingShingle | Nayron Medeiros Soares Gabriela Magalhães Pereira Ana Carolina Leonardi Dutra Nathalie Ribeiro Artigas Júlia Schneider Krimberg Bruno Elkfury Monticelli Artur Francisco Schumacher-Schuh Rosa Maria Martins de Almeida Carlos Roberto de Mello Rieder Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease Arquivos de Neuro-Psiquiatria parkinson disease uric acid dyskinesias levodopa |
| title | Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease |
| title_full | Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease |
| title_fullStr | Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease |
| title_full_unstemmed | Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease |
| title_short | Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease |
| title_sort | low serum uric acid levels and levodopa induced dyskinesia in parkinson s disease |
| topic | parkinson disease uric acid dyskinesias levodopa |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761294 |
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