Association between suicide attempts and anemia in late-life depression inpatients
Abstract Background Anemia is strongly associated with late-life depression (LLD), however, few studies have investigated the relationship between anemia and suicide attempts in LLD patients. It is still challenging to predict suicide risk in patients with depression. Therefore, there is growing int...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-023-04649-9 |
| _version_ | 1797355495562936320 |
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| author | Jie Li Lan Wang Ziyi Wang Fengxue Zhao Yadi Sun Ying Lu Lei Yang |
| author_facet | Jie Li Lan Wang Ziyi Wang Fengxue Zhao Yadi Sun Ying Lu Lei Yang |
| author_sort | Jie Li |
| collection | DOAJ |
| description | Abstract Background Anemia is strongly associated with late-life depression (LLD), however, few studies have investigated the relationship between anemia and suicide attempts in LLD patients. It is still challenging to predict suicide risk in patients with depression. Therefore, there is growing interest in potential biomarkers of depressive disorders and suicidal behavior, which may play a significant role in the early diagnosis and treatment of depression. This study aimed to compare serum ferritin, folate, vitamin B12, and erythrocyte parameter levels in patients with LLD with those in healthy older adults, and the relationship between serum ferritin, folate, vitamin B12, and suicide attempts in patients. Methods Serum ferritin, folate, vitamin B12, and erythrocyte parameter levels were measured in 66 hospitalized LLD patients (30 without suicide attempt, 36 with suicide attempt) and 47 healthy individuals. All participants were surveyed for basic conditions and suicide attempts, and depression was assessed in LLD patients. Results Serum ferritin, folate, vitamin B12, red blood cell count, hemoglobin, hematocrit, mean platelet volume and plateletcrit levels were significantly lower in LLD patients compared with healthy older adults (P < 0.05). Further analysis of the relationship between serum ferritin, folate, and vitamin B12 levels and LLD patients’ suicide attempts and showed a significant negative association between serum folate and vitamin B12 and suicide attempts (P < 0.05). Conclusions Serum ferritin, folate, vitamin B12, red blood cell count, hemoglobin, hematocrit, mean platelet volume and plateletcrit levels were significantly lower in LLD patients than in healthy older adults. In addition, reduced serum folate and vitamin B12 levels in patients may have some effect on suicide attempts. More mechanistic studies are needed to further explain this association. |
| first_indexed | 2024-03-08T14:11:59Z |
| format | Article |
| id | doaj.art-3aee5c0708294b22814b3a2fcefbd41e |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-08T14:11:59Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-3aee5c0708294b22814b3a2fcefbd41e2024-01-14T12:35:36ZengBMCBMC Geriatrics1471-23182024-01-012411710.1186/s12877-023-04649-9Association between suicide attempts and anemia in late-life depression inpatientsJie Li0Lan Wang1Ziyi Wang2Fengxue Zhao3Yadi Sun4Ying Lu5Lei Yang6The Second Affiliated Hospital, School of Nursing, Xinxiang Medical UniversityThe Second Affiliated Hospital, School of Nursing, Xinxiang Medical UniversityThe Second Affiliated Hospital, School of Nursing, Xinxiang Medical UniversityThe Second Affiliated Hospital, School of Nursing, Xinxiang Medical UniversityThe Second Affiliated Hospital, School of Nursing, Xinxiang Medical UniversityNursing Department of Henan Provincial People’s HospitalThe Second Affiliated Hospital, School of Nursing, Xinxiang Medical UniversityAbstract Background Anemia is strongly associated with late-life depression (LLD), however, few studies have investigated the relationship between anemia and suicide attempts in LLD patients. It is still challenging to predict suicide risk in patients with depression. Therefore, there is growing interest in potential biomarkers of depressive disorders and suicidal behavior, which may play a significant role in the early diagnosis and treatment of depression. This study aimed to compare serum ferritin, folate, vitamin B12, and erythrocyte parameter levels in patients with LLD with those in healthy older adults, and the relationship between serum ferritin, folate, vitamin B12, and suicide attempts in patients. Methods Serum ferritin, folate, vitamin B12, and erythrocyte parameter levels were measured in 66 hospitalized LLD patients (30 without suicide attempt, 36 with suicide attempt) and 47 healthy individuals. All participants were surveyed for basic conditions and suicide attempts, and depression was assessed in LLD patients. Results Serum ferritin, folate, vitamin B12, red blood cell count, hemoglobin, hematocrit, mean platelet volume and plateletcrit levels were significantly lower in LLD patients compared with healthy older adults (P < 0.05). Further analysis of the relationship between serum ferritin, folate, and vitamin B12 levels and LLD patients’ suicide attempts and showed a significant negative association between serum folate and vitamin B12 and suicide attempts (P < 0.05). Conclusions Serum ferritin, folate, vitamin B12, red blood cell count, hemoglobin, hematocrit, mean platelet volume and plateletcrit levels were significantly lower in LLD patients than in healthy older adults. In addition, reduced serum folate and vitamin B12 levels in patients may have some effect on suicide attempts. More mechanistic studies are needed to further explain this association.https://doi.org/10.1186/s12877-023-04649-9Late-life depressionAnemiaSuicide attemptSerum ferritinFolateVitamin B12 |
| spellingShingle | Jie Li Lan Wang Ziyi Wang Fengxue Zhao Yadi Sun Ying Lu Lei Yang Association between suicide attempts and anemia in late-life depression inpatients BMC Geriatrics Late-life depression Anemia Suicide attempt Serum ferritin Folate Vitamin B12 |
| title | Association between suicide attempts and anemia in late-life depression inpatients |
| title_full | Association between suicide attempts and anemia in late-life depression inpatients |
| title_fullStr | Association between suicide attempts and anemia in late-life depression inpatients |
| title_full_unstemmed | Association between suicide attempts and anemia in late-life depression inpatients |
| title_short | Association between suicide attempts and anemia in late-life depression inpatients |
| title_sort | association between suicide attempts and anemia in late life depression inpatients |
| topic | Late-life depression Anemia Suicide attempt Serum ferritin Folate Vitamin B12 |
| url | https://doi.org/10.1186/s12877-023-04649-9 |
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