Evaluation of Lung Density and Its Dosimetric Impact on Lung Cancer Radiotherapy: A Simulation Study
Background: The dosimetric parameters required in lung cancer radiation therapy are taken from a homogeneous water phantom; however, during treatment, the expected results are being affected because of its inhomogeneity. Therefore, it becomes necessary to quantify these deviations. Objective: The...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2019-02-01
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| Series: | Journal of Biomedical Physics and Engineering |
| Subjects: | |
| Online Access: | http://jbpe.ir/Journal_OJS/JBPE/index.php/jbpe/article/view/430/305 |
| _version_ | 1818154669458849792 |
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| author | Raj Verma T. Kumar Painuly N. Prasad Mishra S. Yoganathan S. A. Singh N. Bhatt M. L. B. Jamal N. |
| author_facet | Raj Verma T. Kumar Painuly N. Prasad Mishra S. Yoganathan S. A. Singh N. Bhatt M. L. B. Jamal N. |
| author_sort | Raj Verma T. |
| collection | DOAJ |
| description | Background: The dosimetric parameters required in lung cancer radiation therapy
are taken from a homogeneous water phantom; however, during treatment, the expected results are being affected because of its inhomogeneity. Therefore, it becomes
necessary to quantify these deviations.
Objective: The present study has been undertaken to find out inter- and intralung density variations and its dosimetric impact on lung cancer radiotherapy using
Monte Carlo code FLUKA and PBC algorithms.
Material and Methods: Density of 100 lungs was recorded from their CT
images along with age. Then, after PDD calculated by FLUKA MC Code and PBC
algorithm for virtual phantom having density 0.2 gm/cm3
and 0.4 gm/cm3
(density
range obtained from CT images of 100 lungs) using Co-60 10 x10 cm2
beams were
compared.
Results: Average left and right lung densities were 0.275±0.387 and 0.270±0.383
respectively. The deviation in PBC calculated PDD were (+)216%, (+91%), (+)45%,
(+)26.88%, (+)14%, (-)1%, (+)2%, (-)0.4%, (-)1%, (+)1%, (+)4%, (+)4.5% for
0.4 gm/cm3
and (+)311%, (+)177%, (+)118%, (+)90.95%, (+)72.23%, (+)55.83%
,(+)38.85%, (+)28.80%, (+)21.79%, (+)15.95%, (+)1.67%, (-) 2.13%, (+)1.27%,
(+)0.35%, (-)1.79%, (-)2.75% for 0.2 gm/cm3
density mediums at depths of 1mm,
2mm, 3mm, 4mm, 5mm, 6 mm, 7 mm, 8mm, 9mm,10mm, 15mm, 30mm, 40mm,
50mm, 80mm and 100 mm, respectively.
Conclusion: Large variations in inter- and intra- lung density were recorded.
PBC overestimated the dose at air/lung interface as well as inside lung. The results
of Monte Carlo simulation can be used to assess the performance of other treatment
planning systems used in lung cancer radiotherapy. |
| first_indexed | 2024-12-11T14:30:11Z |
| format | Article |
| id | doaj.art-3aee73c330044495b143e74d5b410e26 |
| institution | Directory Open Access Journal |
| issn | 2251-7200 2251-7200 |
| language | English |
| last_indexed | 2024-12-11T14:30:11Z |
| publishDate | 2019-02-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Biomedical Physics and Engineering |
| spelling | doaj.art-3aee73c330044495b143e74d5b410e262022-12-22T01:02:29ZengShiraz University of Medical SciencesJournal of Biomedical Physics and Engineering2251-72002251-72002019-02-01911728Evaluation of Lung Density and Its Dosimetric Impact on Lung Cancer Radiotherapy: A Simulation StudyRaj Verma T.0Kumar Painuly N.1Prasad Mishra S.2Yoganathan S. A.3Singh N.4Bhatt M. L. B.5Jamal N.6King George Medical University, UP, Lucknow, IndiaKing George Medical University, UP, Lucknow, IndiaDr.Ram Manohar Lohia Institute of Medical Sciences, Lucknow, IndiaSanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India King George Medical University, UP, Lucknow, IndiaKing George Medical University, UP, Lucknow, IndiaKing George Medical University, UP, Lucknow, IndiaBackground: The dosimetric parameters required in lung cancer radiation therapy are taken from a homogeneous water phantom; however, during treatment, the expected results are being affected because of its inhomogeneity. Therefore, it becomes necessary to quantify these deviations. Objective: The present study has been undertaken to find out inter- and intralung density variations and its dosimetric impact on lung cancer radiotherapy using Monte Carlo code FLUKA and PBC algorithms. Material and Methods: Density of 100 lungs was recorded from their CT images along with age. Then, after PDD calculated by FLUKA MC Code and PBC algorithm for virtual phantom having density 0.2 gm/cm3 and 0.4 gm/cm3 (density range obtained from CT images of 100 lungs) using Co-60 10 x10 cm2 beams were compared. Results: Average left and right lung densities were 0.275±0.387 and 0.270±0.383 respectively. The deviation in PBC calculated PDD were (+)216%, (+91%), (+)45%, (+)26.88%, (+)14%, (-)1%, (+)2%, (-)0.4%, (-)1%, (+)1%, (+)4%, (+)4.5% for 0.4 gm/cm3 and (+)311%, (+)177%, (+)118%, (+)90.95%, (+)72.23%, (+)55.83% ,(+)38.85%, (+)28.80%, (+)21.79%, (+)15.95%, (+)1.67%, (-) 2.13%, (+)1.27%, (+)0.35%, (-)1.79%, (-)2.75% for 0.2 gm/cm3 density mediums at depths of 1mm, 2mm, 3mm, 4mm, 5mm, 6 mm, 7 mm, 8mm, 9mm,10mm, 15mm, 30mm, 40mm, 50mm, 80mm and 100 mm, respectively. Conclusion: Large variations in inter- and intra- lung density were recorded. PBC overestimated the dose at air/lung interface as well as inside lung. The results of Monte Carlo simulation can be used to assess the performance of other treatment planning systems used in lung cancer radiotherapy.http://jbpe.ir/Journal_OJS/JBPE/index.php/jbpe/article/view/430/305PBCMonte Carlo Code FLUKAVariation in Lung DensityVirtual PhantomComputed Tomography |
| spellingShingle | Raj Verma T. Kumar Painuly N. Prasad Mishra S. Yoganathan S. A. Singh N. Bhatt M. L. B. Jamal N. Evaluation of Lung Density and Its Dosimetric Impact on Lung Cancer Radiotherapy: A Simulation Study Journal of Biomedical Physics and Engineering PBC Monte Carlo Code FLUKA Variation in Lung Density Virtual Phantom Computed Tomography |
| title | Evaluation of Lung Density and Its Dosimetric Impact on Lung Cancer Radiotherapy: A Simulation Study |
| title_full | Evaluation of Lung Density and Its Dosimetric Impact on Lung Cancer Radiotherapy: A Simulation Study |
| title_fullStr | Evaluation of Lung Density and Its Dosimetric Impact on Lung Cancer Radiotherapy: A Simulation Study |
| title_full_unstemmed | Evaluation of Lung Density and Its Dosimetric Impact on Lung Cancer Radiotherapy: A Simulation Study |
| title_short | Evaluation of Lung Density and Its Dosimetric Impact on Lung Cancer Radiotherapy: A Simulation Study |
| title_sort | evaluation of lung density and its dosimetric impact on lung cancer radiotherapy a simulation study |
| topic | PBC Monte Carlo Code FLUKA Variation in Lung Density Virtual Phantom Computed Tomography |
| url | http://jbpe.ir/Journal_OJS/JBPE/index.php/jbpe/article/view/430/305 |
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