Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/4/1313 |
| _version_ | 1797603793296162816 |
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| author | Nimeet Desai Dhwani Rana Sagar Salave Raghav Gupta Pranav Patel Bharathi Karunakaran Amit Sharma Jyotsnendu Giri Derajram Benival Nagavendra Kommineni |
| author_facet | Nimeet Desai Dhwani Rana Sagar Salave Raghav Gupta Pranav Patel Bharathi Karunakaran Amit Sharma Jyotsnendu Giri Derajram Benival Nagavendra Kommineni |
| author_sort | Nimeet Desai |
| collection | DOAJ |
| description | Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science. |
| first_indexed | 2024-03-11T04:37:07Z |
| format | Article |
| id | doaj.art-3aee7fd81c394866a0a8b35cd4460151 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T04:37:07Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3aee7fd81c394866a0a8b35cd44601512023-11-17T20:55:42ZengMDPI AGPharmaceutics1999-49232023-04-01154131310.3390/pharmaceutics15041313Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical ApplicationsNimeet Desai0Dhwani Rana1Sagar Salave2Raghav Gupta3Pranav Patel4Bharathi Karunakaran5Amit Sharma6Jyotsnendu Giri7Derajram Benival8Nagavendra Kommineni9Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaDepartment of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaCenter for Biomedical Research, Population Council, New York, NY 10065, USAChitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science.https://www.mdpi.com/1999-4923/15/4/1313chitosanchitindrug deliverytissue regenerationwound healing |
| spellingShingle | Nimeet Desai Dhwani Rana Sagar Salave Raghav Gupta Pranav Patel Bharathi Karunakaran Amit Sharma Jyotsnendu Giri Derajram Benival Nagavendra Kommineni Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications Pharmaceutics chitosan chitin drug delivery tissue regeneration wound healing |
| title | Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications |
| title_full | Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications |
| title_fullStr | Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications |
| title_full_unstemmed | Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications |
| title_short | Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications |
| title_sort | chitosan a potential biopolymer in drug delivery and biomedical applications |
| topic | chitosan chitin drug delivery tissue regeneration wound healing |
| url | https://www.mdpi.com/1999-4923/15/4/1313 |
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