Establishment of LC-MS/MS Method for Determination of GMDTC in Rat Plasma and Its Application in Preclinical Pharmacokinetics

Establishment of LC-MS/MS Method for Determination of GMDTC in Rat Plasma and Its Application in Preclinical Pharmacokinetics

Sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)-4(methylthio)butanoate (GMDTC) is the first compound to use cadmium repellent as an indication. In this paper, we established and validated a bioanalytical method for the determination of GMDTC in rat plasma, and used i...

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Bibliographic Details
Main Authors: Wei Hu, Zhi-Yong Zhong, Yu-Ting Gao, Xue-Feng Ren, Hai-Yang Liu, Xiao-Jiang Tang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
GMDTC
cadmium
pharmacokinetic
LC–MS/MS
bioanalytical method
Online Access:https://www.mdpi.com/1420-3049/28/3/1191

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