Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence

Staphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasin...

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Main Authors: Rachel Bartash, Priya Nori
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:International Journal of Infectious Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971217301984
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author Rachel Bartash
Priya Nori
author_facet Rachel Bartash
Priya Nori
author_sort Rachel Bartash
collection DOAJ
description Staphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasing development of multidrug resistance. Therefore, there has been increasing interest in combination therapy for the treatment of these infections. The aim of this review was to summarize and assess the evidence supporting combination beta-lactam therapy for both Staphylococcus aureus and Enterococcus species blood stream infections. Currently, there is promising in vitro data but little clinical evidence supporting combination beta-lactam therapy for this indication. Further clinical investigations are needed to elucidate the potential benefits of beta-lactam combination therapy over monotherapy for Gram-positive bacteremia, although combination therapy may be useful in refractory cases of bacteremia that do not respond to standard antibiotic therapy.
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spelling doaj.art-3af18ddaaf5142f0bdc2eeb6c6d9a0a32022-12-21T23:56:13ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112017-10-0163C71210.1016/j.ijid.2017.07.019Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidenceRachel BartashPriya NoriStaphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasing development of multidrug resistance. Therefore, there has been increasing interest in combination therapy for the treatment of these infections. The aim of this review was to summarize and assess the evidence supporting combination beta-lactam therapy for both Staphylococcus aureus and Enterococcus species blood stream infections. Currently, there is promising in vitro data but little clinical evidence supporting combination beta-lactam therapy for this indication. Further clinical investigations are needed to elucidate the potential benefits of beta-lactam combination therapy over monotherapy for Gram-positive bacteremia, although combination therapy may be useful in refractory cases of bacteremia that do not respond to standard antibiotic therapy.http://www.sciencedirect.com/science/article/pii/S1201971217301984Staphylococcus aureusMethicillin-resistant Staphylococcus aureusEnterococcus speciesVancomycin-resistant EnterococcusCombination antibiotic therapyBeta-lactam antibiotic therapy
spellingShingle Rachel Bartash
Priya Nori
Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence
International Journal of Infectious Diseases
Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus
Enterococcus species
Vancomycin-resistant Enterococcus
Combination antibiotic therapy
Beta-lactam antibiotic therapy
title Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence
title_full Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence
title_fullStr Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence
title_full_unstemmed Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence
title_short Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence
title_sort beta lactam combination therapy for the treatment of staphylococcus aureus and enterococcus species bacteremia a summary and appraisal of the evidence
topic Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus
Enterococcus species
Vancomycin-resistant Enterococcus
Combination antibiotic therapy
Beta-lactam antibiotic therapy
url http://www.sciencedirect.com/science/article/pii/S1201971217301984
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