Immunodeficiencies and autoimmune diseases: common variable immunodeficiency and Crohn-like
Background: Common variable immunodeficiency (CVI) gives a major risk of principally respiratory and digestive infections. It is associated with autoimmune diseases, granulomatous process and neoplasias. The digestive clinic is common, in 10% of patients it is the only symptom, and 60% present chron...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Aran Ediciones
|
| Series: | Revista Espanola de Enfermedades Digestivas |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000800019&lng=en&tlng=en |
| _version_ | 1818650171425161216 |
|---|---|
| author | Cristina Saldaña-Dueñas Saioa Rubio-Iturria |
| author_facet | Cristina Saldaña-Dueñas Saioa Rubio-Iturria |
| author_sort | Cristina Saldaña-Dueñas |
| collection | DOAJ |
| description | Background: Common variable immunodeficiency (CVI) gives a major risk of principally respiratory and digestive infections. It is associated with autoimmune diseases, granulomatous process and neoplasias. The digestive clinic is common, in 10% of patients it is the only symptom, and 60% present chronic diarrhea. Clinically it can be confused and related with other pathologies such as inflammatory bowel disease which is infrequent (2-13%). Case report: We present the case of a patient with CVI with digestive symptoms being diagnosed of Crohn-like disease with extent ileal affectation. The main treatment of these patients is the same as classical Crohn disease although in the most severe cases, as this one, the use of immunosupresors is necessary. At this time the patient remains on clinical remmision with infliximab. She presented a previous adverse reaction with adalimumab. Discussion: The few case series in this pathology makes the treatment with immunomodulators in this immunodeficiency a real diagnostic and therapeutic challenge. |
| first_indexed | 2024-12-17T01:45:58Z |
| format | Article |
| id | doaj.art-3af32d8e84274f7baebaf392fc93effa |
| institution | Directory Open Access Journal |
| issn | 1130-0108 |
| language | English |
| last_indexed | 2024-12-17T01:45:58Z |
| publisher | Aran Ediciones |
| record_format | Article |
| series | Revista Espanola de Enfermedades Digestivas |
| spelling | doaj.art-3af32d8e84274f7baebaf392fc93effa2022-12-21T22:08:11ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-0108108852052310.17235/reed.2015.3872/2015S1130-01082016000800019Immunodeficiencies and autoimmune diseases: common variable immunodeficiency and Crohn-likeCristina Saldaña-Dueñas0Saioa Rubio-Iturria1Complejo Hospitalario de NavarraComplejo Hospitalario de NavarraBackground: Common variable immunodeficiency (CVI) gives a major risk of principally respiratory and digestive infections. It is associated with autoimmune diseases, granulomatous process and neoplasias. The digestive clinic is common, in 10% of patients it is the only symptom, and 60% present chronic diarrhea. Clinically it can be confused and related with other pathologies such as inflammatory bowel disease which is infrequent (2-13%). Case report: We present the case of a patient with CVI with digestive symptoms being diagnosed of Crohn-like disease with extent ileal affectation. The main treatment of these patients is the same as classical Crohn disease although in the most severe cases, as this one, the use of immunosupresors is necessary. At this time the patient remains on clinical remmision with infliximab. She presented a previous adverse reaction with adalimumab. Discussion: The few case series in this pathology makes the treatment with immunomodulators in this immunodeficiency a real diagnostic and therapeutic challenge.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000800019&lng=en&tlng=enInmunodeficiencia común variableEnfermedad inflamatoria intestinalAnti-TNFα |
| spellingShingle | Cristina Saldaña-Dueñas Saioa Rubio-Iturria Immunodeficiencies and autoimmune diseases: common variable immunodeficiency and Crohn-like Revista Espanola de Enfermedades Digestivas Inmunodeficiencia común variable Enfermedad inflamatoria intestinal Anti-TNFα |
| title | Immunodeficiencies and autoimmune diseases: common variable immunodeficiency and Crohn-like |
| title_full | Immunodeficiencies and autoimmune diseases: common variable immunodeficiency and Crohn-like |
| title_fullStr | Immunodeficiencies and autoimmune diseases: common variable immunodeficiency and Crohn-like |
| title_full_unstemmed | Immunodeficiencies and autoimmune diseases: common variable immunodeficiency and Crohn-like |
| title_short | Immunodeficiencies and autoimmune diseases: common variable immunodeficiency and Crohn-like |
| title_sort | immunodeficiencies and autoimmune diseases common variable immunodeficiency and crohn like |
| topic | Inmunodeficiencia común variable Enfermedad inflamatoria intestinal Anti-TNFα |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000800019&lng=en&tlng=en |
| work_keys_str_mv | AT cristinasaldanaduenas immunodeficienciesandautoimmunediseasescommonvariableimmunodeficiencyandcrohnlike AT saioarubioiturria immunodeficienciesandautoimmunediseasescommonvariableimmunodeficiencyandcrohnlike |