Glycine/NMDA Receptor Pathway Mediates the Rapid-onset Antidepressant Effect of Alkaloids From Trichilia Monadelpha

Glycine/NMDA Receptor Pathway Mediates the Rapid-onset Antidepressant Effect of Alkaloids From Trichilia Monadelpha

Introduction: Major depressive disorder is often associated with suicidal tendencies, and this condition accentuates the need for rapid-acting antidepressants. We previously reported that Alkaloids (ALK) from Trichilia monadelpha possess antidepressant action in acute animal models of depression and...

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Bibliographic Details
Main Authors: Kennedy Kwami Edem Kukuia, Jeffrey Amoako Mensah, Patrick Amoateng, Dorcas Osei-Safo, Awo Efua Koomson, Joseph Torbi, Donatus Wewura Adongo, Elvis Ofori Ameyaw, Inemesit Okon Ben, Seth Kwabena Amponsah, Kwasi Agyei Bugyei, Isaac Julius Asiedu-Gyekye
Format: Article
Language:English
Published: Iran University of Medical Sciences 2021-05-01
Series:Basic and Clinical Neuroscience
Subjects:
glycine/nmda receptor
open space swim test
rapid-acting antidepressant
trichilia
alkaloids
Online Access:http://bcn.iums.ac.ir/article-1-1907-en.html

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