Computational mechanistic investigation of the kinetic resolution of α-methyl-phenylacetaldehyde by norcoclaurine synthase
Abstract Norcoclaurine synthase from Thalictrum flavum (TfNCS) demonstrated high stereospecificity and yield in catalyzing the Pictet-Spengler reaction of dopamine with chiral aldehydes, achieving kinetic resolution of aldehydes. However, the mechanism and the factors contributing to the stereoselec...
Main Authors: | Shiqing Zhang, Chenghua Zhang, Aijing Guo, Baoyan Liu, Hao Su, Xiang Sheng |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-03-01
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Series: | Communications Chemistry |
Online Access: | https://doi.org/10.1038/s42004-024-01146-x |
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