Computational mechanistic investigation of the kinetic resolution of α-methyl-phenylacetaldehyde by norcoclaurine synthase

Computational mechanistic investigation of the kinetic resolution of α-methyl-phenylacetaldehyde by norcoclaurine synthase

Abstract Norcoclaurine synthase from Thalictrum flavum (TfNCS) demonstrated high stereospecificity and yield in catalyzing the Pictet-Spengler reaction of dopamine with chiral aldehydes, achieving kinetic resolution of aldehydes. However, the mechanism and the factors contributing to the stereoselec...

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Bibliographic Details
Main Authors:	Shiqing Zhang, Chenghua Zhang, Aijing Guo, Baoyan Liu, Hao Su, Xiang Sheng
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Series:	Communications Chemistry
Online Access:	https://doi.org/10.1038/s42004-024-01146-x

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