Autoantibodies in Patients with Fasciolosis
"nBackground: Antiself humoral immune responses have been detected not only in classical autoimmune diseases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic diseases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmun...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2009-07-01
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| Series: | Iranian Journal of Parasitology |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/14222.pdf&manuscript_id=14222 |
| _version_ | 1818872799810289664 |
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| author | M Korkmaz M Şahin B Cicioğlu Aridoğan E Sesli Çetin M Demirci S Kaya |
| author_facet | M Korkmaz M Şahin B Cicioğlu Aridoğan E Sesli Çetin M Demirci S Kaya |
| author_sort | M Korkmaz |
| collection | DOAJ |
| description | "nBackground: Antiself humoral immune responses have been detected not only in classical autoimmune diseases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic diseases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some antibodies related to hepatobiliary systems, in patients with fasciolosis. "nMethods: Thirty-two patients (17 males, 15 females) with fasciolosis were included in this case-control study. Anti-nuclear antibodies (ANA) Screen (antigen mixture of dsDNA, histones, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere) ELISA and single-antigen ELISAs for detection of some antibodies (dsDNA, Anti-M2, Anti- liver-kidney microsomes type 1 (LKM-1) and Myeloperoxidase (MPO) were carried out. "nResults: ANA-screen, M-2, LKM-1, MPO and anti-dsDNA positivity were detected with ELISA in 7, 7, 4, 2 and 2 of 32 patients with fasciolosis, consecutively. No statistically significant difference was detected for any of the autoantibodies' frequency between patients with fasciolosis and control group. However, autoantibody positivity rate was significantly higher in patients with fasciolosis (50 %) than control group (12.5 %). Absorbance values of all autoantibodies in patients with fasciolosis were statistically significant higher than controls. "nConclusion: These results lent support to the role of fasciolosis as a trigger factor of autoimmune reactivity by the breakdown of tolerance. In spite of the extensive knowledge that has accumulated, the specific relationship between fasciolosis and autoimmunity is still obscure. |
| first_indexed | 2024-12-19T12:44:33Z |
| format | Article |
| id | doaj.art-3af6cf58bd084e85b1bfaa6ccf267b38 |
| institution | Directory Open Access Journal |
| issn | 1735-7020 2008-238X |
| language | English |
| last_indexed | 2024-12-19T12:44:33Z |
| publishDate | 2009-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Parasitology |
| spelling | doaj.art-3af6cf58bd084e85b1bfaa6ccf267b382022-12-21T20:20:50ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2009-07-01433239Autoantibodies in Patients with FasciolosisM KorkmazM ŞahinB Cicioğlu AridoğanE Sesli ÇetinM DemirciS Kaya"nBackground: Antiself humoral immune responses have been detected not only in classical autoimmune diseases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic diseases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some antibodies related to hepatobiliary systems, in patients with fasciolosis. "nMethods: Thirty-two patients (17 males, 15 females) with fasciolosis were included in this case-control study. Anti-nuclear antibodies (ANA) Screen (antigen mixture of dsDNA, histones, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere) ELISA and single-antigen ELISAs for detection of some antibodies (dsDNA, Anti-M2, Anti- liver-kidney microsomes type 1 (LKM-1) and Myeloperoxidase (MPO) were carried out. "nResults: ANA-screen, M-2, LKM-1, MPO and anti-dsDNA positivity were detected with ELISA in 7, 7, 4, 2 and 2 of 32 patients with fasciolosis, consecutively. No statistically significant difference was detected for any of the autoantibodies' frequency between patients with fasciolosis and control group. However, autoantibody positivity rate was significantly higher in patients with fasciolosis (50 %) than control group (12.5 %). Absorbance values of all autoantibodies in patients with fasciolosis were statistically significant higher than controls. "nConclusion: These results lent support to the role of fasciolosis as a trigger factor of autoimmune reactivity by the breakdown of tolerance. In spite of the extensive knowledge that has accumulated, the specific relationship between fasciolosis and autoimmunity is still obscure.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/14222.pdf&manuscript_id=14222 FasciolosisAutoantibodyAutoimmunity |
| spellingShingle | M Korkmaz M Şahin B Cicioğlu Aridoğan E Sesli Çetin M Demirci S Kaya Autoantibodies in Patients with Fasciolosis Iranian Journal of Parasitology Fasciolosis Autoantibody Autoimmunity |
| title | Autoantibodies in Patients with Fasciolosis |
| title_full | Autoantibodies in Patients with Fasciolosis |
| title_fullStr | Autoantibodies in Patients with Fasciolosis |
| title_full_unstemmed | Autoantibodies in Patients with Fasciolosis |
| title_short | Autoantibodies in Patients with Fasciolosis |
| title_sort | autoantibodies in patients with fasciolosis |
| topic | Fasciolosis Autoantibody Autoimmunity |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/14222.pdf&manuscript_id=14222 |
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