Rilpivirine and Dolutegravir Simultaneously Measured via RP-HPLC-PDA with Box–Behnken Design Application: A Study of Forced Degradation under Various Conditions

Rilpivirine and Dolutegravir Simultaneously Measured via RP-HPLC-PDA with Box–Behnken Design Application: A Study of Forced Degradation under Various Conditions

Simultaneous estimation of rilpivirine (RLVN) and dolutegravir (DTGR) in bulk and tablet dosage forms via RP-HPLC-PDA with a Box–Behnken design (BBD) has been performed in this study to develop a fast, precise, timely and cost-saving method for estimating RLVN and DTGR in bulk and tablet dosage form...

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Bibliographic Details
Main Authors: Shadma Wahab, Mohammad Khalid, Sarfaraz Ahmad, Sherouk Hussein Sweilam
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Separations
Subjects:
RP-HPLC
PDA detector
Box–Behnken design
ICH guidelines
degradation studies
cost-effective
Online Access:https://www.mdpi.com/2297-8739/10/3/185

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