Chronic Exposure to Chewing Tobacco Induces Metabolic Reprogramming and Cancer Stem Cell-Like Properties in Esophageal Epithelial Cells

Chronic Exposure to Chewing Tobacco Induces Metabolic Reprogramming and Cancer Stem Cell-Like Properties in Esophageal Epithelial Cells

Tobacco in its smoke and smokeless form are major risk factors for esophageal squamous cell carcinoma (ESCC). However, molecular alterations associated with smokeless tobacco exposure are poorly understood. In the Indian subcontinent, tobacco is predominantly consumed in chewing form. An understandi...

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Bibliographic Details
Main Authors: Keshava K. Datta, Shankargouda Patil, Krishna Patel, Niraj Babu, Remya Raja, Vishalakshi Nanjappa, Kiran Kumar Mangalaparthi, Bharti Dhaka, Pavithra Rajagopalan, Sayali Chandrashekhar Deolankar, Ramakrishnan Kannan, Prashant Kumar, T. S. Keshava Prasad, Premendu P. Mathur, Anjali Kumari, Malini Manoharan, Karunakaran Coral, Saktivel Murugan, David Sidransky, Ravi Gupta, Rohit Gupta, Arati Khanna-Gupta, Aditi Chatterjee, Harsha Gowda
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
mitochondria
cancer metabolism
tobacco
proteomics
exome sequencing
electron microscopy
Online Access:https://www.mdpi.com/2073-4409/8/9/949

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