Development of an RNase H2 Activity Assay for Clinical Screening

Development of an RNase H2 Activity Assay for Clinical Screening

As the key enzyme mediating ribonucleotide excision repair, RNase H2 is essential for the removal of single ribonucleotides from DNA in order to prevent genome damage. Loss of RNase H2 activity directly contributes to the pathogenesis of autoinflammatory and autoimmune diseases and might further pla...

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Bibliographic Details
Main Authors: Marian Simon Schulz, Cay Bennet Sartorius von Bach, Emilija Marinkovic, Claudia Günther, Rayk Behrendt, Axel Roers
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Journal of Clinical Medicine
Subjects:
RNase H2
fluorometric assay
clinical screening
systemic sclerosis
systemic lupus erythemathosus
assay validation
Online Access:https://www.mdpi.com/2077-0383/12/4/1598

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